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Oral bioavailability assessment : basics and strategies for drug discovery and development

Author: Ayman F El-Kattan
Publisher: Hoboken, NJ : John Wiley & Sons Inc., 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
El-Kattan, Ayman F.
Oral bioavailability assessment.
Hoboken, NJ : John Wiley & Sons Inc., 2017
(DLC) 2016055388
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ayman F El-Kattan
ISBN: 9781118916940 1118916948 9781118916933 111891693X 9781118916926 1118916921
OCLC Number: 965446691
Description: 1 online resource
Contents: Drug pharmacokinetics and toxicokinetics --
GIT anatomy and physiology and drug oral bioavailability : impact of species differences --
Drug routes of excretion --
Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion --
Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect --
Impact of intestinal efflux transporters on oral absorption --
Impact of influx transporters on drug --
Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery --
In vitro and in situ approaches to measure intestinal permeability and efflux transporters --
In silico approaches to predict intestinal permeability --
In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption --
In vitro approaches to assess haptic metabolism and first pass effect --
The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
Responsibility: Ayman F. El-Kattan.

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