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Oral drug absorption : prediction and assessment

Author: J B Dressman; Hans Lennernäs
Publisher: New York : Marcel Dekker, ©2000.
Series: Drugs and the pharmaceutical sciences, 106.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
A study of drug absorption, from the theoretical stages of computer-based calculations to practical guidelines. It examines the interrelationship between the physiology of the gastrointestinal tract and oral drug formulations and absorption, and applications of pharmacokinetic analysis.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Oral drug absorption.
New York : Marcel Dekker, ©2000
(DLC) 00038331
(OCoLC)43854168
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: J B Dressman; Hans Lennernäs
ISBN: 0585387656 9780585387659 0824741986 9780824741983 0203904664 9780203904664
OCLC Number: 49569021
Notes: Includes index.
Description: 1 online resource (x, 330 pages) : illustrations.
Contents: I. Gastrointestinal variables --
Gastrointestinal transit and drug absorption --
Permeability in the gastrointestinal tract --
Gastrointestinal disease and dosage form performance --
II. Membrane permeability --
Intestinal permeability: prediction from theory --
In vitro methods for the assessment of permeability --
Animal perfusion studies --
Human perfusion studies --
The role of permeability studies in preclinical evaluation --
III. Solubility and drug dissolution --
Solubility as a limiting factor to drug absorption --
Dissolution testing of immediate-release products --
Dissolution testing in the development or oral drug products --
Analysis of drug dissolution data --
IV. In vivo-in vitro correlations --
Convolution and deconvolution methods --
The correlation of in vitro and in vivo drug dissolution --
IVIVC: a perspective from the workbench.
Series Title: Drugs and the pharmaceutical sciences, 106.
Responsibility: edited by Jennifer B. Dressman, Hans Lennernäs.

Abstract:

A guide for developing oral drug products, this comprehensive reference runs the gamut from theoretical stages of computer-based calculations to practical guidelines for establishing in vitro/in vivo  Read more...

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