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Pancreatic cancer : with special focus on topical issues and surgical techniques

Author: Sun-Whe Kim; Hiroki Yamaue
Publisher: Berlin, Germany : Springer, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sun-Whe Kim; Hiroki Yamaue
ISBN: 9783662471814 3662471817 3662471809 9783662471807
OCLC Number: 986538772
Notes: Includes index.
Description: 1 online resource (xvii, 472 pages) : illustrations (some color)
Contents: Preface; Contents; List of Editors; Contributors; Part I: Pathology and Tumor Biology; 1: Epidemiology; 1.1 Epidemiology of Pancreatic Cancer; 1.1.1 Incidence; 1.1.2 Mortality; 1.1.3 Survival; 1.1.4 Risk Factors; References; 2: Molecular Alterations in Pancreatic Cancer; 2.1 Introduction; 2.2 Genetic Alterations in PDAs; 2.3 KRAS and the Mitogen-ƯActivated Protein Kinase Pathway; 2.4 TP53; 2.5 CDKN2A; 2.6 SMAD4; 2.7 Chromatin Modification Genes; 2.8 DNA Repair-Associated Genes; 2.9 RNA Processing Genes; 2.10 Wnt Pathway Genes. 2.11 Phosphatidylinositol 3-Kinase (PI3K) Pathway Genes2.12 Molecular Mechanism of Development of PDA; 2.13 Genetic Alterations in Intraductal Papillary Mucinous Neoplasms; 2.14 Familial Pancreatic Cancer; 2.15 Implication of Molecular Alterations in Clinical Practice; References; 3: Pathological Classification; 3.1 Ductal Neoplasms; 3.1.1 Invasive Ductal Adenocarcinoma; 3.1.2 Pancreatic Intraepithelial Neoplasia (PanIN); 3.1.3 Other Carcinomas of Ductal Origin; 3.1.4 Intraductal Neoplasms; 3.1.4.1 Intraductal Papillary Mucinous Neoplasms. 3.1.4.2 Intraductal Tubulopapillary Neoplasms3.1.5 Mucinous Cystic Neoplasms; 3.1.6 Serous Cystic Tumors; 3.1.7 Pancreatic Neuroendocrine Tumors; 3.1.8 Acinar Neoplasms; 3.1.9 Solid Pseudopapillary Neoplasm; 3.1.10 Pancreatoblastoma; 3.1.11 Miscellaneous Cystic Pancreatic Lesions; 3.1.12 Pseudotumors; 3.1.13 Mesenchymal Tumors; 3.1.14 Secondary Tumors; References; 4: Controversial Issues in Pathological Diagnosis; References; 5: Operative Specimen Handling and Evaluation of Resection Margins; 5.1 Introduction; 5.2 Specimen Orientation and External Inspection. 5.2.1 Pancreatoduodenectomy Specimens5.2.1.1 Specimen Orientation; 5.2.1.2 External Examination; 5.2.2 Distal Pancreatectomy Specimens; 5.3 Specimen Fixation; 5.3.1 Specimen Handling Prior to Fixation; 5.3.2 Specimen Fixation; 5.4 Inking of the Specimen Surface; 5.5 Specimen Dissection; 5.5.1 Axial Slicing of Pancreatoduodenectomy Specimens; 5.5.2 Advantages of the Axial Slicing Technique; 5.5.3 Dissection of Distal and Total Pancreatectomy Specimens; 5.5.4 Dissection of Extended Pancreatectomy Specimens; 5.6 Macroscopic Examination. 5.6.1 Identification of Anatomical Structures in Pancreatoduodenectomy Specimens5.6.2 Identification of Anatomical Structures in Distal Pancreatectomy Specimens; 5.6.3 Macroscopic Description; 5.7 Photodocumentation; 5.8 Tissue Sampling; 5.8.1 Sampling Technique; 5.8.2 Sampling of Transection Margins; 5.8.3 Sampling from Specimens with Venous or Arterial Resection; 5.8.4 Sampling from Extended Pancreatic Resection Specimens; 5.8.5 Routinely Sampled Tissues; 5.8.6 Block Key; 5.9 Assessment of the Margin Status; 5.9.1 Macroscopic Examination.
Responsibility: Sun-Whe Kim, Hiroki Yamaue, editors.

Abstract:

This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. It is essential,  Read more...

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