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|Additional Physical Format:||Print version:
Caffrey, Conor R.
Hoboken : John Wiley & amp; Sons, ©2012
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Conor R Caffrey; P M Selzer
|Description:||1 online resource (542 pages).|
|Contents:||Parasitic Helminths: Targets, Screens, Drugs and Vaccines; Foreword to Parasitic Helminths: Targets, Screens, Drugs and Vaccines; Contents; Preface; List of Contributors; Part One: Targets; 1 Ligand-Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current, and Future Perspectives; Introduction; Established LGIC Anthelmintic Drug Targets; GluCls --
Targets for Ivermectin; L-Type nAChRs -Targets for Levamisole, Pyrantel, Morantel, and Tribendimidine; nAChRs (DEG-3 Group) --
Targets for AADs; GABA-Gated Chloride Channels --
Targets for Piperazine. Evaluating Possible Anthelmintic Targets for the FutureN-Type nAChRs; Nematode-Specific nAChRs and Orphan nAChR-Like Subunits; GABA Receptor Cation Channels; 5-HT Channels; ACh Chloride Channels; GGR-1 Group; GGR-3 Group; LGC-45 Group; Ungrouped Subunits; Cys-Loop LGIC Superfamilies of Other Nematodes; Genomics; Chemistry-to-Gene Screens to Identify New Targets; First Crystal Structure of a Cys-Loop LGIC Complexed with a Commercial Animal Health Drug; Conclusions and Future Lines of Research; References. 2 How Relevant is Caenorhabditis elegans as a Model for the Analysis of Parasitic Nematode Biology?Introduction; Comparative Genome Analysis for the Phylum Nematoda; Functional Characterization of Parasite Genes by Heterologous Expression in C. elegans; Comparative Pharmacology of C. elegans and Parasitic Nematode Neurotransmitter Receptors; C. elegans as a Tool to Understand the Mode of Action of Novel Anthelmintics; C. elegans as a Platform for Target Discovery; Conclusions; References; 3 Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets. IntroductionAvailability of Genome Sequence Information for Parasitic Helminths; Overview of Genome Annotation Datasets that Aid Target Identification; Orthology-Based Annotations and Comparative Genomics; Predictions of Essentiality; Orthology-Based RNAi Phenotype Data Mapping Between C. elegans and Parasitic Helminths; The TDR Targets Database; Target Prioritization in B. malayi and S. mansoni Using the TDR Targets Database; Currently Unavailable Genomic Datasets that will Improve Target Prioritization for Parasitic Helminths; Conclusions; Acknowledgments; References. 4 Recent Progress in Transcriptomics of Key Gastrointestinal Nematodes of Animals --
Fundamental Research Toward New Intervention StrategiesIntroduction; Recent Developments in the Bioinformatic Tools and Pipelines for the Analysis of Expressed Sequence Tag Data; Characterizing the Transcriptomes of Strongylid Nematodes; Conclusions and Prospects; Acknowledgments; References; 5 Harnessing Genomic Technologies to Explore the Molecular Biology of Liver Flukes-Major Implications for Fundamental and Applied Research; Introduction.
|Series Title:||Drug discovery in infectious diseases.|
|Responsibility:||edited by Conor R. Caffrey.|
"This book clearly demonstrates the need of a more unified scientific community for developing successful strategies, by working together and building a strong network of active cooperations with