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Peptide drug discovery and development : translational research in academia and industry

Author: Miguel A R B Castanho; Nuno Santos; Wiley InterScience (Online service)
Publisher: Weinheim : Wiley-VCH, ©2011.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly  Read more...

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Genre/Form: Electronic books
Case studies
Additional Physical Format: Print version:
Peptide drug discovery and development.
Weinheim : Wiley-VCH, ©2011
(OCoLC)751833775
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Miguel A R B Castanho; Nuno Santos; Wiley InterScience (Online service)
ISBN: 9783527636730 3527636730 9783527636754 3527636757
OCLC Number: 761319845
Description: 1 online resource (xix, 370 pages) : illustrations
Contents: Front Matter --
The Academia-Market Bouncing of Peptide Drugs : Challenges and Strategies in Translational Research with Peptide Drugs. Peptides as Leads for Drug Discovery / Paul J Edwards, Steven R LaPlante --
Marketing Antimicrobial Peptides: A Critical Academic Point of View / Eduard Bardaj̕ --
Oral Peptide Drug Delivery: Strategies to Overcome Challenges / Josias H Hamman, Jan H Steenekamp --
Rational Design of Amphipathic a-Helical and Cyclic [beta]- Sheet Antimicrobial Peptides: Specificity and Therapeutic Potential / Wendy J Hartsock, Robert S Hodges --
Conotoxin-Based Leads in Drug Design / Muharrem Akcan, David J Craik --
Plant Antimicrobial Peptides: From Basic Structures to Applied Research / Suzana M Ribeiro, Simoni C Dias, Octavio L Franco --
Peptide Drugs' Translational Tales : Peptide Drugs before, Through and after Industry Pipelines. Omiganan Pentahydrochloride: A Novel, Broad-Spectrum Antimicrobial Peptide for Topical Use / Evelina Rubinchik, Dominique Dugourd --
Turning Endogenous Peptides into New Analgesics: The Example of Kyotorphin Derivatives / Marta M B Ribeiro, Isa D Serrano, S̤nia S̀ Santos --
The Development of Romiplostim : A Therapeutic Peptibody Used to Stimulate Platelet Production / Graham Molineux, Ping Wei --
HIV vs. HIV: Turning HIV-Derived Peptides into Drugs / Henri G Franquelim, Pedro M Matos, A Salom̌ Veiga --
Sifuvirtide, A Novel HIV-1 Fusion Inhibitor / Xiaobin Zhang, Hao Wu, Fengshan Wang --
Whither Peptide Drugs? Peptides Shaping the Future of Drug Development. Endogenous Peptides and Their Receptors as Drug Discovery Targets for the Treatment of Metabolic Disease / Mary Ann Pelleymounter, Yuren Wang, Ning Lee --
Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders / Gareth J Sanger, John Broad, David H Alpers --
Of Mice and Men: Translational Research on Amylin Agonism / Jonathan D Roth, Christine M Mack, James L Trevaskis, David G Parkes --
Peptides and Polypeptides as Immunomodulators and Their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases / Ruth Arnon, Michael Sela, Rina Aharoni --
Development of Antibody Fragments for Therapeutic Applications / Sofia Carte-Real, Frederico Aires da Silva, Joao Gonzalves --
Index.
Responsibility: edited by Miguel Castanho and Nuno C. Santos.

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This book illustrates many of the technical prerequisites and describes model systems in which these objectives have been at least partially achieved. It convincingly shows that peptide-based drug Read more...

 
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