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Peptidoglycans as Promoters of Slow-Wave Sleep. II. Somnogenic and Pyrogenic Activities of Some Naturally Occurring Muramyl Peptides; Correlations with Mass Spectrometric Structure Determination.

Author: J M KruegerM L KarnovskyS A MartinJ R PappenheimerK BiemannAll authors
Publisher: Ft. Belvoir Defense Technical Information Center 25 OCT 1984.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
The structures of components of the sleep-promoting material purified from human urine were established by fast atom bombardment-mass spectrometry. We report here that two substances isolated from that preparation, viz. N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-Ala-gamma-Glu-diaminopimelyl-Ala) and that compound lacking the terminal alanine, are active as somnogens. Cerebro-intraventricular administration of  Read more...
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Document Type: Book
All Authors / Contributors: J M Krueger; M L Karnovsky; S A Martin; J R Pappenheimer; K Biemann; MASSACHUSETTS INST OF TECH CAMBRIDGE Dept. of CHEMISTRY.
OCLC Number: 227636166
Notes: See also AD-A150 210.
Description: 4 pages

Abstract:

The structures of components of the sleep-promoting material purified from human urine were established by fast atom bombardment-mass spectrometry. We report here that two substances isolated from that preparation, viz. N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-Ala-gamma-Glu-diaminopimelyl-Ala) and that compound lacking the terminal alanine, are active as somnogens. Cerebro-intraventricular administration of 1 pmol of the glycotetrapeptide was sufficient to induce prolonged excess sleep in rabbits. Findings show that in addition to the muramyl form of peptidoglycan monomers, the anhydro muramyl form, with no reducing end, is compatible with somnogenic activity. Furthermore, the data obtained with a natural product amplify our earlier observations with smaller synthetic molecules of the importance of amidation/deamidation in the structure-activity relationships of muramyl peptides.

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