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Pharmaceutical Process Chemistry.

Author: Takayuki Shioiri; Kunisuke Izawa; Toshiro Konoike
Publisher: Weinheim : Wiley-VCH, 2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical  Read more...
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Genre/Form: Electronic books
Electronic resource
Additional Physical Format: Print version:
Shioiri, Takayuki.
Pharmaceutical Process Chemistry.
Weinheim : Wiley-VCH, ©2010
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Takayuki Shioiri; Kunisuke Izawa; Toshiro Konoike
ISBN: 9783527633685 3527633685 9783527633692 3527633693
OCLC Number: 707067581
Description: 1 online resource (528 pages)
Contents: Cover13; --
Contents --
Preface --
List of Contributors --
1 From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs --
1.1 Introduction --
1.2 The Synthetic Development of the Monoamine Oxidase-B Inhibitor LazabemideTM --
1.3 The Synthetic Development of the Lipase Inhibitor Tetrahydrolipstatin (XenicalTM) --
1.4 The Synthetic Development of the HIV Protease Inhibitor Saquinavir (InviraseTM) --
1.5 The Synthetic Development of the Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (TamifluTM) --
1.5.1 Introduction --
1.5.2 The Development of the Current Technical Synthesis of Oseltamivir Phosphate --
1.5.3 The Search for Alternative Routes to Oseltamivir Phosphate --
References --
2 Design of Dynamic Salt Catalysts Based on Acid8211;Base Combination Chemistry --
2.1 Introduction --
2.2 Dehydrative Condensation Catalysts --
2.2.1 Esterification Catalysts --
2.2.2 Dehydrative Cyclocondensation Catalysts --
2.3 Asymmetric Mannich-Type Catalysts --
References --
3 Asymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile Oxidant --
3.1 Introduction --
3.2 Asymmetric Epoxidation --
3.2.1 Asymmetric Epoxidation with Synthetic Enzymes or Organocatalysts --
3.2.2 Metal-Catalyzed Asymmetric Epoxidation of Unfunctionalized Olefins --
3.2.3 Metal-Catalyzed Asymmetric Epoxidation of Allylic Alcohols --
3.3 Asymmetric Oxidation of Sulfides --
3.3.1 Metal8211;Salen-Catalyzed Oxidation --
3.3.2 Metal8211;Schiff Base-Catalyzed Oxidation --
3.3.3 Metal8211;ONNO8211;Tetradentate Ligand-Catalyzed Oxidation (Including cis-946; Metal8211;Salen-Catalyzed Oxidation) --
3.3.4 Miscellaneous --
3.4 Conclusion --
References --
4 Development of Palladium Catalysts for Chemoselective Hydrogenation --
4.1 Catalyst Poisons and Chemoselective Heterogeneous Catalysts --
4.1.1 Background --
4.1.2 Chemoselective Inhibition of the Hydrogenolysis for O-Benzyl Protective Groups by the Addition of a Nitrogen-Containing Base --
4.1.3 Pd/C(en) Complex as a Heterogeneous Chemoselective Hydrogenation Catalyst --
4.1.4 Pd/C (Ph2S) Complex as a Heterogeneous Chemoselective Hydrogenation Catalyst --
4.2 Catalyst Supports and Chemoselective Heterogeneous Catalysts --
4.2.1 Pd/Fib as a Silk-Fibroin-Supported Chemoselective Hydrogenation Catalyst --
4.2.2 Pd-PEI as a Partial Hydrogenation Catalyst of Alkynes to Alkenes --
4.3 Summary --
Acknowledgment --
References --
5 Silicon-Based Carbon8211;Carbon Bond Formation by Transition Metal Catalysis --
5.1 Introduction --
5.2 Cross-Coupling Reactions --
5.2.1 Brief Assessment of Early Stage Protocols --
5.2.2 Cross-Coupling Reactions Using Tetraorganosilanes through Intramolecular Activation --
5.2.3 Cross-Coupling Reactions Using Organosilanolates --
5.2.4 Other Tetraorganosilicon Compounds for Cross-Coupling Chemistry --
5.2.5 New Types of Electrophiles for Silicon-Based Cross-Coupling --
5.3 Carbonyl Addition Reaction --
5.3.1 Rhodium-Catalyzed Reactions --
5.3.2 Nickel-Catalyzed Reactions --
5.3.3 Palladium-Catalyzed Reactions --
5.3.4 Copper-Catalyzed Reactions --
5.3.5 Silver-Catalyzed Reactions --
5.4 Recent Developments in Catalytic Preparation of Organosilanes --
References --
6 Direct Reductive Amination with Amine Boranes --
6.1 Introduction --
6.2 Types of Amine Boranes --
6.2.1 Alkylamine Boranes --
6.2.2 Aromatic Amine Boranes --
6.3 Comparison to Sodium Triacetoxyborohydride (STAB) --
T$2944.

Abstract:

Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial  Read more...

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