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Pharmacokinetic challenges in drug discovery

Author: R O Pelkonen; A Baumann; A Reichel
Publisher: Berlin ; New York : Springer, ©2002.
Series: Ernst Schering Research Foundation workshop, 37.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Database:WorldCat
Summary:

One of the biggest pharmaceutical challenges is the pharmacokinetic optimization of drug candidates tailored to have absorption, distribution, metabolism and excretion characteristics in humans. This  Read more...

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Genre/Form: Congresses
Conference papers and proceedings
Additional Physical Format: Online version:
Pharmacokinetic challenges in drug discovery.
Berlin ; New York : Springer, ©2002
(OCoLC)785051264
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: R O Pelkonen; A Baumann; A Reichel
ISBN: 3540425853 9783540425854
OCLC Number: 48475512
Description: xiv, 301 pages : illustrations ; 22 cm.
Contents: 1. Accelerating the Process of Drug Discovery / A. M. Davis, J. Dixon and C. J. Logan / [et al.] --
2. The Role of Pharmacokinetics in Drug Discovery: Finding Drug Candidates with the Greatest Potential for Success / J. H. Lin --
3. Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption / G. S. J. Mannens, H. Bohets and P. Verboven / [et al.] --
4. Drug Metabolism Assays and Their Use in Drug Discovery / M. K. Bayliss and P. J. Eddershaw --
5. Prediction of Human Pharmacokinetics Based on Preclinical In Vitro and In Vivo Data / T. Lave, O. Luttringer and J. Zuegge / [et al.] --
6. In Vitro Screening of Cytochrome P450 Induction Potential / O. Pelkonen, J. Hukkanen and P. Honkakoski / [et al.] --
7. Drug Transport Across the Blood-Brain Barrier / G. Fricker --
8. The Development and Implementation of Bioanalytical Methods Using LC-MS to Support ADME Studies in Early Drug Discovery and Candidate Selection / T. V. Olah --
9. Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening / A. K. Mandagere --
10. High-Throughput Screening --
Brains Versus Brawn / D. A. Smith --
11. Relation of Molecular Properties with Drug Absorption and Disposition / H. van de Waterbeemd --
12. Modelling Human Cytochrome P450-Substrate Interactions / D. F. V. Lewis --
13. Forum Discussion.
Series Title: Ernst Schering Research Foundation workshop, 37.
Responsibility: O. Pelkonen, A. Baumann, A. Reichel, editors.
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