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Pharmacokinetics : an introduction

Author: Erich Gladtke; H M von Hattingberg
Publisher: Berlin ; New York : Springer-Verlag, 1979.
Edition/Format:   Print book : EnglishView all editions and formats
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In their own right, the editors have conducted excellent and unique research on the effect and fate of drugs and have followed up the unexpected changes in drug action accompanying the rapid  Read more...

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Additional Physical Format: Online version:
Gladtke, Erich.
Pharmacokinetics.
Berlin ; New York : Springer-Verlag, 1979
(OCoLC)567423987
Online version:
Gladtke, Erich.
Pharmacokinetics.
Berlin ; New York : Springer-Verlag, 1979
(OCoLC)608730789
Document Type: Book
All Authors / Contributors: Erich Gladtke; H M von Hattingberg
ISBN: 0387091831 9780387091839 3540091831 9783540091837
OCLC Number: 4491834
Notes: Translation of the 2d rev. ed. of Pharmakokinetik.
Description: xi, 141 pages : illustrations ; 21 cm
Contents: I. Volume of Distribution.- II. Compartments.- 1. Protein Binding.- 2. Gastrointestinal Reabsorption.- III. Elimination.- 1. Equation for Elimination.- a) Theoretical Initial Concentration.- b) Half-Time of Elimination.- c) Rate Constant of Elimination.- d) Total Clearance.- e) Saturation Kinetics.- f) Determination of Pharmacokinetic Data from Urine.- IV. Steady State.- 1. Conditions for a Steady State.- a) The Exchangeable Pool.- b) Experimental Analysis of a Natural Steady State.- c) Endogenous Transfer.- 2. Artificial Steady State - Continous Infusion.- V. Multicompartment Systems.- 1. The Model.- a) Invasion.- b) Concentration-Time Curve for Simultaneous Invasion and Elimination.- c) The Bateman Function.- 2. Dost's Principle of Corresponding Areas.- a) Test of Completeness of Invasion.- b) Rule of Corresponding Areas as a Supplement to the Basic Pharmacokinetic Experiment.- 3. Dost's Rule of Corresponding Fractional Areas.- a) Fractional Quantities and Fractional Areas.- b) Conversion of Areas to Quantities of Substance.- 4. General Consideration of Multicompartment Models.- a) Multi-Exponential Function.- b) Subdivision into Individual e-Functions.- c) Practical Importance of the C; y-Expression.- VI. Pharmacokinetics and Treatment.- 1. Repeated Administration of a Drug.- a) Duration of Accumulation.- b) Degree of Accumulation.- VII. Pharmacokinetics of Gastrointestinal Absorption.- 1. Gastrointestinal Absorption and the Bateman Function.- 2. Reconstruction of the Invasion Curves.- 3. Use of the Invasion Curves.- 4. Calculation of Dose-Proportional Absorption.- 5. Variants of the Invasion Process in Gastrointestinal Absorption.- a) Variants in the Site of Absorption.- b) Delay in Invasion Due to Lymphatic Transport of Lipid-Soluble Substances.- c) Physical and Chemical Reactions After Absorption.- d) Excretion and Reabsorption of Substances in the Intestine.- e) Limitation of the Absorptive Capacity.- f) Different Absorptive Capacity of Two Segments of Intestine.- 6. Conclusions.- 7. Appendix: Some Formulae and Their Derivation.- VIII. Interaction.- 1 Elimination.- a) Pathological Changes in the Organ of Excretion.- b) Age-Dependent Changes in Elimination.- c) Pharmacogenetic Factors.- d) Dependence of Rate of Elimination on Acid-Base Balance.- e) Circadian Rhythm of Excretion Rate.- f) Water Diuresis and Rate of Elimination.- g) Solvent Deficiency.- h) Enzyme Induction.- i) Inhibition of Elimination by Toxicity.- 2. Volume of Distribution.- a) Hydration and Dehydration.- b) Hydropic States.- 3. Conclusions.- IX. Use of Analogue Computers in Pharmacokinetics.- 1. Principle of the Analogue Computer.- 2. Programming the Analogue Computer.- 3. Use.- X. Practical Application of Pharmacokinetic Procedures.- 1. Methods of Measurement.- a) Microbiological Methods.- b) Chemical Analysis.- c) Radioactively Labelled Substances.- 2. Assessment of the Results of Animal Experiments.- 3. Derivation of Pharmacokinetic Parameters and Constants.- a) Calculation from a Graph.- b) Programmend Procedures.- 4. Mathematical Basis of Programming.- a) Distribution of a Substance Between Several Compartments.- b) Blood Concentration-Time Curves for Pure Invasion.- c) Blood Concentration-Time Curves for Pure Elimination.- d) Blood Concentration-Time Curves for Simultaneous Invasion and Elimination (Batemann Function).- e) Accumulation, Limiting Curve.- f) Dosage Scheme.- 5. Examples of Calculation.- Further Reading.
Other Titles: Pharmakokinetik.
Responsibility: E. Gladtke, H.M. von Hattingberg, with contributions by W. Kübler, W.-H. Wagner ; and a foreword by E.R. Garrett translated ; by P.J. Wilkinson.

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