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Pharmacokinetics and pharmacodynamics of biotech drugs : principles and case studies in drug development

Author: Bernd Meibohm
Publisher: Weinheim, Germany : Wiley-VCH, ©2006.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Pharmacokinetics and pharmacodynamics of biotech drugs.
Weinheim, Germany : Wiley-VCH, ©2006
(OCoLC)70174012
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Bernd Meibohm
ISBN: 9783527609628 3527609628 9783527609529 3527609520
OCLC Number: 86175793
Description: 1 online resource (xxi, 403 pages) : illustrations
Contents: The role of pharmacokinetics and pharmacodynamics in the development of biotech drugs / Bernd Meibohm --
Pharmacokinetics of peptides and proteins / Lisa Tang, Bernd Meibohm --
Pharmacokinetics of monoclonal antibodies / Katharina Kuester, Charlotte Kloft --
Pharmacokinetics and pharmacodynamics of antisense oligonucleotides / Rosie Z. Yu, Richard S. Geary, Arthur A. Levin --
Pharmacokinetics of viral and non-viral gene delivery vectors / Martin Meyer, Gururaj Rao, Ke Ren, Jeffrey Hughes --
Bioanalytical methods used for pharmacokinetic evaluations of biotech macromolecule drugs : issues, assay approaches, and limitations / Jean W. Lee --
Limitations of noncompartmental pharmacokinetic analysis of biotech drugs / Arthur B. Straughn --
Bioequivalence of biologics / Jeffrey S. Barrett --
Biopharmaceutical challenges: pulmonary delivery of proteins and peptides / Kun Cheng, Ram I. Mahato --
Biopharmaceutical challenges : delivery of oligonucleotides / Lloyd G. Tillman, Gregory E. Hardee --
Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs / Francesco M. Veronese, Paolo Caliceti --
Exposure-response relationships for therapeutic biologic products / Mohammad Tabrizi, Lorin K. Roskos --
Preclinical and clinical drug development of tasidotin, a depsi-pentapeptide oncolytic agent / Peter L. Bonate, Larry Arthaud, Katherine Stephenson --
Clinical drug development of cetuximab, a monoclonal antibody / Arno Nolting, Floyd E. Fox, Andreas Kovar --
Integration of pharmacokinetics and pharmacodynamics into the drug development of pegfilgrastim, a pegylated protein / Bing-Bing Yang.
Responsibility: edited by Bernd Meibohm.

Abstract:

Provides coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals. This book discusses such challenges and opportunities as pulmonary delivery of proteins and  Read more...

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.".. There is an urgent need to understand the PK and PD characteristics of these different types of drugs. This book meets that need. ..."Anticancer Research

 
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