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Pharmacokinetics and toxicokinetics

Author: Mehdi Boroujerdi
Publisher: Boca Raton, FL : CRC Press LLC, [2015]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The Influence of Routes of Administration on ADMEIntroductionPharmacokinetics (PK) and Pharmacodynamics (PD)Toxicokinetics (TK) and Toxicodynamics (TD)Concepts Basic to PK and TKInfluence of Routes of Exposure/Administration on PK/TK analysisBiomarkersReferencesMechanisms of Absorption and Permeation of XenobioticsIntroductionPassive DiffusionCarrier-Mediated Transcellular DiffusionTranscellular Diffusion Subject to  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Boroujerdi, Mehdi
Pharmacokinetics and Toxicokinetics
Hoboken : CRC Press,c2015
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mehdi Boroujerdi
ISBN: 9781482221350 1482221357
OCLC Number: 903644072
Description: 1 online resource
Contents: Chapter 1. The influence of routes of administration on ADME --
chapter 2. Mechanisms of absorption and permeation of xenobiotics --
chapter 3. In Vivo distribution of xenobiotics --
chapter 4. Elimination rate, clearance, and the theoretical models --
chapter 5. Renal excretion of xenobiotics and estimation of related PK/TK parameters and constants --
chapter 6. Biotransformation of xenobiotics --
chapter 7. Kinetics of In Vitro metabolism : assimilation of intrinsic clearance in hepatic clearance --
chapter 8. Pharmaceutical, biopharmaceutical, and physiological factors influencing oral absorption : mechanistic absorption models --
chapter 9. Mathematical modeling in pharmacokinetics and toxicokinetics --
chapter 10. PK/TK analysis of instantaneous exposure to xenobiotics (single bolus injection) --
chapter 11. PK/TK analysis of continuous zero-order exposure to xenobiotics (intravenous infusion) --
chapter 12. PK/TK analysis of xenobiotics absorbed via an extravascular route of administration (oral administration) --
chapter 13. PK/TK of xenobiotics absorbed through the skin (transdermal absorption) --
chapter 14. PK/TK analysis of multiple dosing --
chapter 15. Bioavailability, bioequivalence, and biosimilar evaluations --
chapter 16. Preclinical PK/TK and clinical trials --
chapter 17. Population pharmacokinetics/toxicokinetics --
chapter 18. Quantitative extrapolation interspecies scaling/low dose extrapolation.
Responsibility: Mehdi Boroujerdi.
More information:

Abstract:

The Influence of Routes of Administration on ADMEIntroductionPharmacokinetics (PK) and Pharmacodynamics (PD)Toxicokinetics (TK) and Toxicodynamics (TD)Concepts Basic to PK and TKInfluence of Routes of Exposure/Administration on PK/TK analysisBiomarkersReferencesMechanisms of Absorption and Permeation of XenobioticsIntroductionPassive DiffusionCarrier-Mediated Transcellular DiffusionTranscellular Diffusion Subject to P-Glycoprotein EffluxActive TransportEndocytosis and PinocytosisSolvent Drag, Osmosis, and Two-Pore TheoryIon-Pair AbsorptionReferencesIn Vivo Distribution of XenobioticsIntroducti.

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