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A pharmacology primer : theory, applications, and methods

Author: Terrence P Kenakin
Publisher: Burlington, MA ; London, UK : Elsevier Academic Press, ©2006.
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Summary:

Dealing with the basics of pharmacology, this work features historical facts in pharmacology. It contains a section on therapeutics to help readers identify with diseases and drug treatments. It also  Read more...

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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Terrence P Kenakin
ISBN: 0080465307 9780080465302
OCLC Number: 441768756
Description: 1 online resource (xviii, 299 pages) : illustrations (some color), portraits
Contents: Cover --
Front cover --
Foreword to Second Edition --
Foreword to First Edition --
Table of Contents --
1 What Is Pharmacology? --
1.1 About This Book --
1.2 What Is Pharmacology? --
1.3 The Receptor Concept --
1.4 Pharmacological Test Systems --
1.5 The Nature of Drug Receptors --
1.6 Pharmacological Intervention and the Therapeutic Landscape --
1.7 System-independent Drug Parameters: Affinity and Efficacy --
1.8 What Is Affinity? --
1.9 The Langmuir Adsorption Isotherm --
1.10 What Is Efficacy? --
1.11 Dose-response Curves --
1.12 Chapter Summary and Conclusions --
1.13 Derivations: Conformational Selections as a Mechanism of Efficacy --
2 How Different Tissues Process Drug Response --
2.1 Drug Response as Seen Through the ''Cellular Veil'' --
2.2 The Biochemical Nature of Stimulus-response Cascades --
2.3 The Mathematical Approximation of Stimulus-response Mechanisms --
2.4 System Effects on Agonist Response: Full and Partial Agonists --
2.5 Differential Cellular Response to Receptor Stimulus --
2.6 Receptor Desensitization and Tachyphylaxis --
2.7 The Measurement of Drug Activity --
2.8 Advantages and Disadvantages of Different Assay Formats --
2.9 Drug Concentration as an Independent Variable --
2.10 Chapter Summary and Conclusions --
2.11 Derivations --
3 Drug-Receptor Theory --
3.1 About This Chapter --
3.2 Drug-Receptor Theory --
3.3 The Use of Mathematical Models in Pharmacology --
3.4 Some Specific Uses of Models in Pharmacology --
3.5 Classical Model of Receptor Function --
3.6 The Operational Model of Receptor Function --
3.7 Two-state Theory --
3.8 The Ternary Complex Model --
3.9 The Extended Ternary Model --
3.10 Constitutive Receptor Activity --
3.11 The Cubic Ternary Complex Model --
3.12 Chapter Summary and Conclusions --
3.13 Derivations --
4 Pharmacological Assay Formats: Binding --
4.1 The Structure of This Chapter --
4.2 Binding Theory and Experiment --
4.3 Complex Binding Phenomena: Agonist Affinity from Binding Curves --
4.4 Experimental Prerequisites for Correct Application of Binding Techniques --
4.5 Chapter Summary and Conclusions --
4.6 Derivations --
5 Agonists: The Measurement of Affinity and Efficacy in Functional Assays --
5.1 Functional Pharmacological Experiments --
5.2 The Choice of Functional Assays --
5.3 Recombinant Functional Systems --
5.4 Functional Experiments: Dissimulation in Time --
5.5 Experiments in Real Time Versus Stop Time --
5.6 The Measurement of Agonist Affinity in Functional Experiments --
5.7 Estimates of Relative Efficacy of Agonists in Functional Experiments --
5.8 Chapter Summary and Conclusions --
5.9 Derivations --
6 Orthosteric Drug Antagonism --
6.1 Introduction --
6.2 Kinetics of Drug-Receptor Interaction --
6.3 Surmountable Competitive Antagonism --
6.4 Noncompetitive Antagonism --
6.5 Agonist-Antagonist Hemi-equilibria --
6.6 Resultant Analysis --
6.7 Chapter Summary and Conclusions --
6.8 Derivations --
7 Allosteric Drug Antagonism --
7.1 Introduction --
7.2 The Nature of Receptor Allosterism --
7.3 Properties of Allosteric Modulators --
7.4 Functional Study of Allosteric Modula.
Responsibility: Terry Kenakin.

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