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Pharmacophores and pharmacophore searches

Author: Thierry Langer; Rémy D Hoffmann
Publisher: Weinheim : Wiley-VCH, ©2006.
Series: Methods and principles in medicinal chemistry, 32.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

The first handbook to address the practical aspects of this novel method, providing a complete overview and progressing from general considerations to real life drug discovery scenarios. A valuable  Read more...

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Genre/Form: Aufsatzsammlung
Document Type: Book
All Authors / Contributors: Thierry Langer; Rémy D Hoffmann
ISBN: 9783527312504 3527312501
OCLC Number: 67873893
Description: xx, 375 pages : illustrations.
Contents: Pharmacophores : historical perspective and viewpoint from a medicinal chemist / Camille G. Wermuth --
Pharmacophore model generation software tools / Konstantin Poptodorov, Tien Luu, Rémy D. Hoffmann --
Alignment-free pharmacophore patterns, a correlation-vector approach / Steffen Renner, Uli Fechner, Gisbert Schneider --
Feature trees : theory and applications from large-scale virtual screening to data analysis / Matthias Rarey, Sally Hindle, Patrick Maass, Günther Metz, Christian Rummey, Marc Zimmermann --
Concept and applications of pseudoreceptors / Klaus-Jürgen Schleifer --
Pharmacophores from macromolecular complexes with LigandScout / Gerhard Wolber, Robert Kosara --
Grid-based pharmacophore models : concept and application examples / Francesco Ortuso, Stefano Alcaro, Thierry Langer --
Hot spot analysis of protein-binding sites as a prerequisite for structure-based virtual screening and lead optimization / Ruth Brenk, Gerhard Klebe --
Application of pharmacophore fingerprints to structure-based design and data mining / Prabha Karnachi, Amit Kulkarni --
SIFt : analysis, organization and database mining for protein-inhibitor complexes. Application to protein kinase inhibitors / Juswinder Singh, Zhan Deng, Claudio Chuaqui --
Application of structure-based alignment methods for 3D QSAR analyses / Wolfgang Sippl --
Application of pharmacophore models in medicinal chemistry / Fabrizio Manetti, Maurizio Botta, Andrea Tafi --
GPCR anti-target modeling : pharmacophore models to avoid GPCR-mediated side-effects / Thomas Klabunde --
Pharmacophores for human ADME/Tox-related proteins / Cheng Chang, Sean Ekins --
Are you sure you have a good model? / Nicolas Triballeau, Hugues-Olivier Bertrand, Francine Acher.
Series Title: Methods and principles in medicinal chemistry, 32.
Responsibility: edited by Thierry Langer and Rémy D. Hoffmann.
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'With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid...' (Anticancer Research, 2007)

 
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