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Pharmacoresistance in epilepsy : from genes and molecules to promising therapies

著者: Luisa Rocha; Esper A Cavalheiro
出版商: New York, NY : Springer, ©2013.
版本/格式:   电子图书 : 文献 : 英语查看所有的版本和格式
数据库:WorldCat
提要:
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent  再读一些...
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类型/形式: Electronic books
材料类型: 文献, 互联网资源
文件类型: 互联网资源, 计算机文档
所有的著者/提供者: Luisa Rocha; Esper A Cavalheiro
ISBN: 9781461464648 1461464641
OCLC号码: 843346251
注意: Includes index.
描述: 1 online resource.
内容: Pharmacoresistance and epilepsy / Francisco Rubio-Donnadieu --
Genes involved in pharmacoresistant epilepsy / Iris E. Martínez-Juárez --
Pathological oscillations in the pharmacoresistant epileptic brain / Richard J. Staba --
Molecular mechanisms of pharmacoresistant epilepsy / Alberto Lazarowski, Liliana Czornyj --
Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance / Monica E. Ureña-Guerrero --
Intracellular pathways associated with neuronal survival and death in epilepsy / Martha Rivera-Cervantes, Alfredo I. Feria-Velasco --
The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration / Carme Auladell, Felix Junyent --
Proteomics-based strategy to identify biomarkers and pharmacological Targets in Temporal lobe epilepsy / Maria José da Silva Fernandes, Rebeca Padrão Amorim --
Abnormalities of GABA system and human pharmacoresistant epilepsy / Sandra Orozco-Suárez --
Pharmacoresistant epilepsy and immune system / Lourdes Lorigados Pedre --
Contribution of the antiepileptic drug administration regime in the development and /or establishment of pharmacoresistant epilepsy / Pietro Fagiolino, Marta Vázquez --
Experimental models to study pharmacoresistance in epilepsy / Cecilia Zavala-Tecuapetla, Luisa Rocha --
Resistance to epileptogenesis in the neotropical rodent proechimys / Carla A. Scorza, Esper A. Cavalheiro --
On the development of new antiepileptic drugs for the Treatment of pharmacoresistant epilepsy: different approaches to different hypothesis / Alan Talevi, Luis E. Bruno-Blanch --
Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy / Heidrun Potschka --
Vagus nerve stimulation for intractable seizures / Mario A. Alonso-Vanegas --
The role of neuromodulation in the Treatment of refractory epilepsy / Ana Luisa Velasco, Francisco Velasco --
Transcranial magnetic stimulation and refractory partial epilepsy / Lilia Maria Morales Chacón, Lázaro Gómez Fernández --
Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity / Walter G. Besio --
Physical exercise as a strategy to reduce seizure susceptibility / Ricardo Mario Arida, Fulvio Alexandre Scorza.
责任: Luisa Rocha, Esper A. Cavalheiro, editors.

摘要:

This book examines all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It also details novel therapeutic  再读一些...

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