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Pharmacoresistance in Epilepsy : From Genes and Molecules to Promising Therapies

Author: Luisa Rocha; Esper A Cavalheiro
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition/Format:   Print book : Document   Computer File : EnglishView all editions and formats
Database:WorldCat
Summary:

This book examines all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It also details novel therapeutic  Read more...

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Additional Physical Format: Printed edition:
Pharmacoresistance in Epilepsy
Material Type: Document
Document Type: Book, Computer File
All Authors / Contributors: Luisa Rocha; Esper A Cavalheiro
ISBN: 9781461464648 1461464641
OCLC Number: 940530091
Description: 1 online resource (XII, 329 p. 40 illus., 26 illus. in color.)
Contents: Pharmacoresistance and Epilepsy.- Genes involved in pharmacoresistant epilepsy.- Pathological oscillations in the pharmacoresistant epileptic brain.- Molecular mechanisms of pharmacoresistant epilepsy.- Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance.- Intracellular pathways associated with neuronal survival and death in epilepsy.- The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration.- Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy.- Abnormalities of GABA system and human pharmacoresistant epilepsy.- Pharmacoresistant epilepsy and immune system.- Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy.- Experimental models to study pharmacoresistance in epilepsy.- Resistance to epileptogenesis in the Neotropical rodent Proechimys.- On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy - Different approaches to different hypothesis.- Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy.- Vagus Nerve Stimulation for Intractable Seizures.- The role of neuromodulation in the treatment of refractory epilepsy.- Transcranial magnetic stimulation and refractory partial epilepsy.- Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.- Physical exercise as a strategy to reduce seizure susceptibility.
Responsibility: edited by Luisa Rocha, Esper A. Cavalheiro.
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