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Pharmacotherapy of pulmonary hypertension

Author: Marc Humbert; Oleg V Evgenov; Johannes-Peter Stasch
Publisher: Heidelberg : Springer, 2013.
Series: Handbook of experimental pharmacology, v. 218.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Humbert, Marc.
Pharmacotherapy of Pulmonary Hypertension.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Marc Humbert; Oleg V Evgenov; Johannes-Peter Stasch
ISBN: 9783642386640 3642386644 3642386636 9783642386633
OCLC Number: 861276932
Notes: Includes index.
Description: 1 online resource (ix, 576 pages) : illustrations (some color).
Contents: Part I: Pulmonary Hypertension: Conceptual Bases of the Disease. Definition and Classification of Pulmonary Hypertension / Marc Humbert [and others] --
Pulmonary Hypertension: Pathophysiology and Signaling Pathways / Bradley A. Maron and Joseph Loscalzo --
Pulmonary Hypertension: Pathology / Peter Dorfmüller --
Pulmonary Hypertension: Biomarkers / Christopher J. Rhodes, John Wharton and Martin R. Wilkins --
Rodent Models of Group 1 Pulmonary Hypertension / John J. Ryan, Glenn Marsboom and Stephen L. Archer --
Part II: Pulmonary Hypertension: Established Therapies. General Supportive Care / Ioana R. Preston --
Calcium-Channel Blockers in Pulmonary Arterial Hypertension / Marie-Camille Chaumais, Elise Artaud Macari and Olivier Sitbon --
Prostacyclins / Horst Olschewski --
Endothelin Receptor Antagonists / Martine Clozel, Alessandro Maresta and Marc Humbert --
Phosphodiesterase-5 Inhibitors / Barbara A. Cockrill and Aaron B. Waxman --
Inhaled Nitric Oxide for the Treatment of Pulmonary Arterial Hypertension / Steven H. Abman --
Part III: Pulmonary Hypertension: Novel Pathways and Emerging Therapies. Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension / Johannes-Peter Stasch and Oleg V. Evgenov --
Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction / Michael G. Risbano and Mark T. Gladwin --
Rho-Kinase Inhibitors / Yoshihiro Fukumoto and Hiroaki Shimokawa --
Serotonin Transporter and Serotonin Receptors / Serge Adnot [and others] --
Targeting of Platelet-Derived Growth Factor Signaling in Pulmonary Arterial Hypertension / Eva Berghausen, Henrik ten Freyhaus and Stephan Rosenkranz --
Emerging Molecular Targets for Anti-proliferative Strategies in Pulmonary Arterial Hypertension / Ly Tu and Christophe Guignabert --
Anti-inflammatory and Immunosuppressive Agents in PAH / Jolyane Meloche [and others] --
Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application / Reshma S. Baliga, Raymond J. MacAllister and Adrian J. Hobbs --
Pulmonary Hypertension: Novel Pathways and Emerging Therapies Inhibitors of cGMP and cAMP Metabolism / Yassine Sassi and Jean-Sébastien Hulot --
Pulmonary Hypertension: Old Targets Revisited (Statins, PPARs, Beta-Blockers) / Geoffrey Watson [and others] --
Part IV: Conclusions and Outlook --
Pulmonary Hypertension: Current Management and Future Directions / Lewis J. Rubin.
Series Title: Handbook of experimental pharmacology, v. 218.
Responsibility: Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch, editors.
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