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Phosphoinositides and disease

Author: Marco Falasca
Publisher: Dordrecht ; New York : Springer, ©2012.
Series: Current topics in microbiology and immunology, v. 362.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Phosphoinositides and disease.
(DLC) 2012950382
(OCoLC)819537111
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Marco Falasca
ISBN: 9789400750258 9400750250 9400794266 9789400794269
OCLC Number: 817799592
Language Note: English.
Description: 1 online resource (vi, 318 pages) : illustrations.
Contents: Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles Bisphosphates: Phosphatidylinositol 4,5-bisphosphateKinases; Phosphatases; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,4-bisphosphate; Kinases; Phosphatases; Other Routes of PtdIns(3,4)P2 Turnover; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,5-bisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Phosphatidylinositol 3,4,5-trisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Conclusion; Acknowledgments; References; 2 Phosphoinositides and Cardiovascular Diseases; Abstract; Introduction AtherosclerosisPIP3; IP3; Hypertrophy and Heart Failure; PIP3; IP3; PIP2; Arrhythmias; PIP2; IP3; PIP3; Conclusion; References; 3 Phosphoinositides in Insulin Action and Diabetes; Abstract; Introduction; The Synthesis and Degradation of Phosphoinositides; PI(3,4,5)P3 and PI(3,4)P2; PI(3)P; Regulation of PI(3,5)P2 and PI(5)P Levels; Metabolism of PI(4)P; Synthesis and Degradation of PI(4,5)P2; Relative Levels and Locations of Phosphoinositides; Acute Changes in Phosphoinositides; Phosphoinositides are Key Second Messengers in Insulin Action; Regulation of Akt Signaling Pathways Regulation of mTORC1 SignalingPhosphoinositides Play Key Roles Downstream of Early Signaling in Insulin Action; GLUT4 Trafficking; Insulin Secretion; Glycogen and Lipid Synthesis; Genetics and Pharmacology of Phosphoinositide Disruption; PI(3,4,5)P3 and PI(3,4)P2; Negative Regulators of PI(3,4,5)P3; Phosphoinositide-Metabolizing Enzymes as Drug Targets in Diabetes; Summary; Acknowledgments; References; 4 Phosphoinositides in Neuroexocytosis and Neuronal Diseases; Abstract; The Discovery of the Phosphoinositide Pathway and its Role in Exocytosis; Role of Phosphoinositides and Neuroexocytosis Identification of Phosphoinositide EffectorsLinks to Neurodegenerative Disease; Acknowledgments; References; 5 Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function; Abstract; Physical Properties of Phospholipids Affecting Membrane Morphology and Fusion; Acute and Inducible Modification of Lipids in Endomembranes; Role of Phosphoinositides and DAG on Endomembrane Function and Morphology; Phosphoinositides Associated with the Nucleus; Acknowledgments; References; 6 Molecular Analysis of Protein --
Phosphoinositide Interactions; Abstract; Introduction
Series Title: Current topics in microbiology and immunology, v. 362.
Responsibility: Marco Falasca, editor.

Abstract:

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

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