doorgaan naar inhoud
Phosphoinositides and disease Voorbeeldweergave van dit item
SluitenVoorbeeldweergave van dit item
Bezig met controle...

Phosphoinositides and disease

Auteur: Marco Falasca
Uitgever: Dordrecht ; New York : Springer, ©2012.
Serie: Current topics in microbiology and immunology, v. 362.
Editie/Formaat:   eBoek : Document : EngelsAlle edities en materiaalsoorten bekijken.
Samenvatting:
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of  Meer lezen...
Beoordeling:

(nog niet beoordeeld) 0 met beoordelingen - U bent de eerste

Onderwerpen
Meer in deze trant

 

Zoeken naar een online exemplaar

Links naar dit item

Zoeken naar een in de bibliotheek beschikbaar exemplaar

&AllPage.SpinnerRetrieving; Bibliotheken met dit item worden gezocht…

Details

Genre/Vorm: Electronic books
Aanvullende fysieke materiaalsoort: Print version:
Phosphoinositides and disease.
(DLC) 2012950382
(OCoLC)819537111
Genre: Document, Internetbron
Soort document Internetbron, Computerbestand
Alle auteurs / medewerkers: Marco Falasca
ISBN: 9789400750258 9400750250 9400794266 9789400794269
OCLC-nummer: 817799592
Taalopmerking: English.
Beschrijving: 1 online resource (vi, 318 pages) : illustrations.
Inhoud: Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles. Bisphosphates: Phosphatidylinositol 4,5-bisphosphateKinases; Phosphatases; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,4-bisphosphate; Kinases; Phosphatases; Other Routes of PtdIns(3,4)P2 Turnover; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,5-bisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Phosphatidylinositol 3,4,5-trisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Conclusion; Acknowledgments; References; 2 Phosphoinositides and Cardiovascular Diseases; Abstract; Introduction. AtherosclerosisPIP3; IP3; Hypertrophy and Heart Failure; PIP3; IP3; PIP2; Arrhythmias; PIP2; IP3; PIP3; Conclusion; References; 3 Phosphoinositides in Insulin Action and Diabetes; Abstract; Introduction; The Synthesis and Degradation of Phosphoinositides; PI(3,4,5)P3 and PI(3,4)P2; PI(3)P; Regulation of PI(3,5)P2 and PI(5)P Levels; Metabolism of PI(4)P; Synthesis and Degradation of PI(4,5)P2; Relative Levels and Locations of Phosphoinositides; Acute Changes in Phosphoinositides; Phosphoinositides are Key Second Messengers in Insulin Action; Regulation of Akt Signaling Pathways. Regulation of mTORC1 SignalingPhosphoinositides Play Key Roles Downstream of Early Signaling in Insulin Action; GLUT4 Trafficking; Insulin Secretion; Glycogen and Lipid Synthesis; Genetics and Pharmacology of Phosphoinositide Disruption; PI(3,4,5)P3 and PI(3,4)P2; Negative Regulators of PI(3,4,5)P3; Phosphoinositide-Metabolizing Enzymes as Drug Targets in Diabetes; Summary; Acknowledgments; References; 4 Phosphoinositides in Neuroexocytosis and Neuronal Diseases; Abstract; The Discovery of the Phosphoinositide Pathway and its Role in Exocytosis; Role of Phosphoinositides and Neuroexocytosis. Identification of Phosphoinositide EffectorsLinks to Neurodegenerative Disease; Acknowledgments; References; 5 Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function; Abstract; Physical Properties of Phospholipids Affecting Membrane Morphology and Fusion; Acute and Inducible Modification of Lipids in Endomembranes; Role of Phosphoinositides and DAG on Endomembrane Function and Morphology; Phosphoinositides Associated with the Nucleus; Acknowledgments; References; 6 Molecular Analysis of Protein --
Phosphoinositide Interactions; Abstract; Introduction.
Serietitel: Current topics in microbiology and immunology, v. 362.
Verantwoordelijkheid: Marco Falasca, editor.

Fragment:

This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when  Meer lezen...

Beoordelingen

Beoordelingen door gebruikers
Beoordelingen van GoodReads worden opgehaald...
Bezig met opvragen DOGObooks-reviews...

Tags

U bent de eerste.
Bevestig deze aanvraag

Misschien heeft u dit item reeds aangevraagd. Selecteer a.u.b. Ok als u toch wilt doorgaan met deze aanvraag.

Gekoppelde data


Primary Entity

<http://www.worldcat.org/oclc/817799592> # Phosphoinositides and disease
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "817799592" ;
    library:placeOfPublication <http://dbpedia.org/resource/New_York_City> ; # New York
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1184406615#Place/dordrecht> ; # Dordrecht
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/ne> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/cell_physiological_phenomena> ; # Cell Physiological Phenomena
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/biochemical_phenomena> ; # Biochemical Phenomena
    schema:about <http://id.loc.gov/authorities/subjects/sh89002397> ; # Cellular signal transduction
    schema:about <http://dewey.info/class/572.57/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/signal_transduction> ; # Signal Transduction
    schema:about <http://id.worldcat.org/fast/850288> ; # Cellular signal transduction
    schema:about <http://id.worldcat.org/fast/1054980> ; # Pathology, Molecular
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phenomena_and_processes> ; # Phenomena and Processes
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol_phosphates> ; # Inositol Phosphates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/sugar_phosphates> ; # Sugar Phosphates
    schema:about <http://id.loc.gov/authorities/subjects/sh85101107> ; # Phosphoinositides
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidic_acids> ; # Phosphatidic Acids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemicals_and_drugs> ; # Chemicals and Drugs
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidylinositols> ; # Phosphatidylinositols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phospholipids> ; # Phospholipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/sugar_alcohols> ; # Sugar Alcohols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophosphates> ; # Glycerophosphates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphoinositides_pathophysiology> ; # Phosphoinositides--Pathophysiology
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/membrane_lipids> ; # Membrane Lipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophospholipids> ; # Glycerophospholipids
    schema:about <http://id.loc.gov/authorities/subjects/sh85098691> ; # Pathology, Molecular
    schema:about <http://id.worldcat.org/fast/1061408> ; # Phosphoinositides
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/organic_chemicals> ; # Organic Chemicals
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemical_phenomena> ; # Chemical Phenomena
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/carbohydrates> ; # Carbohydrates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/lipids> ; # Lipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/alcohols> ; # Alcohols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol> ; # Inositol
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/278055514> ; # Marco Falasca
    schema:copyrightYear "2012" ;
    schema:datePublished "2012" ;
    schema:description "Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated."@en ;
    schema:description "Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/1184406615> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/1184406615#Series/current_topics_in_microbiology_and_immunology> ; # Current topics in microbiology and immunology ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/819537111> ;
    schema:name "Phosphoinositides and disease"@en ;
    schema:productID "817799592" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/817799592#PublicationEvent/dordrecht_new_york_springer_2012> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1184406615#Agent/springer> ; # Springer
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=511420> ;
    schema:url <http://dx.doi.org/10.1007/978-94-007-5025-8> ;
    schema:url <http://swbplus.bsz-bw.de/bsz431236240cov.htm> ;
    schema:url <http://link.springer.com/openurl?genre=book&isbn=978-94-007-5024-1> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=1030745> ;
    schema:url <http://site.ebrary.com/id/10617886> ;
    schema:workExample <http://worldcat.org/isbn/9789400750258> ;
    schema:workExample <http://worldcat.org/isbn/9789400794269> ;
    schema:workExample <http://dx.doi.org/10.1007/978-94-007-5025-8> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/817799592> ;
    .


Related Entities

<http://dbpedia.org/resource/New_York_City> # New York
    a schema:Place ;
    schema:name "New York" ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Series/current_topics_in_microbiology_and_immunology> # Current topics in microbiology and immunology ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/817799592> ; # Phosphoinositides and disease
    schema:name "Current topics in microbiology and immunology ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/biochemical_phenomena> # Biochemical Phenomena
    a schema:Intangible ;
    schema:name "Biochemical Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/cell_physiological_phenomena> # Cell Physiological Phenomena
    a schema:Intangible ;
    schema:name "Cell Physiological Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemical_phenomena> # Chemical Phenomena
    a schema:Intangible ;
    schema:name "Chemical Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemicals_and_drugs> # Chemicals and Drugs
    a schema:Intangible ;
    schema:name "Chemicals and Drugs"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophosphates> # Glycerophosphates
    a schema:Intangible ;
    schema:name "Glycerophosphates"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophospholipids> # Glycerophospholipids
    a schema:Intangible ;
    schema:name "Glycerophospholipids"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol_phosphates> # Inositol Phosphates
    a schema:Intangible ;
    schema:name "Inositol Phosphates"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/organic_chemicals> # Organic Chemicals
    a schema:Intangible ;
    schema:name "Organic Chemicals"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phenomena_and_processes> # Phenomena and Processes
    a schema:Intangible ;
    schema:name "Phenomena and Processes"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidic_acids> # Phosphatidic Acids
    a schema:Intangible ;
    schema:name "Phosphatidic Acids"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidylinositols> # Phosphatidylinositols
    a schema:Intangible ;
    schema:name "Phosphatidylinositols"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphoinositides_pathophysiology> # Phosphoinositides--Pathophysiology
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh85101107> ; # Phosphoinositides
    schema:name "Phosphoinositides--Pathophysiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/signal_transduction> # Signal Transduction
    a schema:Intangible ;
    schema:name "Signal Transduction"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85098691> # Pathology, Molecular
    a schema:Intangible ;
    schema:name "Pathology, Molecular"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85101107> # Phosphoinositides
    a schema:Intangible ;
    schema:name "Phosphoinositides"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh89002397> # Cellular signal transduction
    a schema:Intangible ;
    schema:name "Cellular signal transduction"@en ;
    .

<http://id.worldcat.org/fast/1054980> # Pathology, Molecular
    a schema:Intangible ;
    schema:name "Pathology, Molecular"@en ;
    .

<http://id.worldcat.org/fast/1061408> # Phosphoinositides
    a schema:Intangible ;
    schema:name "Phosphoinositides"@en ;
    .

<http://id.worldcat.org/fast/850288> # Cellular signal transduction
    a schema:Intangible ;
    schema:name "Cellular signal transduction"@en ;
    .

<http://viaf.org/viaf/278055514> # Marco Falasca
    a schema:Person ;
    schema:familyName "Falasca" ;
    schema:givenName "Marco" ;
    schema:name "Marco Falasca" ;
    .

<http://worldcat.org/isbn/9789400750258>
    a schema:ProductModel ;
    schema:isbn "9400750250" ;
    schema:isbn "9789400750258" ;
    .

<http://worldcat.org/isbn/9789400794269>
    a schema:ProductModel ;
    schema:isbn "9400794266" ;
    schema:isbn "9789400794269" ;
    .

<http://www.worldcat.org/oclc/819537111>
    a schema:CreativeWork ;
    rdfs:label "Phosphoinositides and disease." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/817799592> ; # Phosphoinositides and disease
    .


Content-negotiable representations

Venster sluiten

Meld u aan bij WorldCat 

Heeft u geen account? U kunt eenvoudig een nieuwe gratis account aanmaken.