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Phosphoinositides and disease

Autor: Marco Falasca
Editora: Dordrecht ; New York : Springer, ©2012.
Séries: Current topics in microbiology and immunology, v. 362.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of  Ler mais...
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Gênero/Forma: Electronic books
Formato Físico Adicional: Print version:
Phosphoinositides and disease.
(DLC) 2012950382
(OCoLC)819537111
Tipo de Material: Documento, Recurso Internet
Tipo de Documento Recursos de internet, Arquivo de computador
Todos os Autores / Contribuintes: Marco Falasca
ISBN: 9789400750258 9400750250 9400794266 9789400794269
Número OCLC: 817799592
Nota do Idioma: English.
Descrição: 1 online resource (vi, 318 pages) : illustrations.
Conteúdos: Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles. Bisphosphates: Phosphatidylinositol 4,5-bisphosphateKinases; Phosphatases; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,4-bisphosphate; Kinases; Phosphatases; Other Routes of PtdIns(3,4)P2 Turnover; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,5-bisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Phosphatidylinositol 3,4,5-trisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Conclusion; Acknowledgments; References; 2 Phosphoinositides and Cardiovascular Diseases; Abstract; Introduction. AtherosclerosisPIP3; IP3; Hypertrophy and Heart Failure; PIP3; IP3; PIP2; Arrhythmias; PIP2; IP3; PIP3; Conclusion; References; 3 Phosphoinositides in Insulin Action and Diabetes; Abstract; Introduction; The Synthesis and Degradation of Phosphoinositides; PI(3,4,5)P3 and PI(3,4)P2; PI(3)P; Regulation of PI(3,5)P2 and PI(5)P Levels; Metabolism of PI(4)P; Synthesis and Degradation of PI(4,5)P2; Relative Levels and Locations of Phosphoinositides; Acute Changes in Phosphoinositides; Phosphoinositides are Key Second Messengers in Insulin Action; Regulation of Akt Signaling Pathways. Regulation of mTORC1 SignalingPhosphoinositides Play Key Roles Downstream of Early Signaling in Insulin Action; GLUT4 Trafficking; Insulin Secretion; Glycogen and Lipid Synthesis; Genetics and Pharmacology of Phosphoinositide Disruption; PI(3,4,5)P3 and PI(3,4)P2; Negative Regulators of PI(3,4,5)P3; Phosphoinositide-Metabolizing Enzymes as Drug Targets in Diabetes; Summary; Acknowledgments; References; 4 Phosphoinositides in Neuroexocytosis and Neuronal Diseases; Abstract; The Discovery of the Phosphoinositide Pathway and its Role in Exocytosis; Role of Phosphoinositides and Neuroexocytosis. Identification of Phosphoinositide EffectorsLinks to Neurodegenerative Disease; Acknowledgments; References; 5 Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function; Abstract; Physical Properties of Phospholipids Affecting Membrane Morphology and Fusion; Acute and Inducible Modification of Lipids in Endomembranes; Role of Phosphoinositides and DAG on Endomembrane Function and Morphology; Phosphoinositides Associated with the Nucleus; Acknowledgments; References; 6 Molecular Analysis of Protein --
Phosphoinositide Interactions; Abstract; Introduction.
Título da Série: Current topics in microbiology and immunology, v. 362.
Responsabilidade: Marco Falasca, editor.

Resumo:

This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when  Ler mais...

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