跳至内容
Phosphoinositides and disease 線上預覽
關閉線上預覽
正在查...

Phosphoinositides and disease

作者: Marco Falasca
出版商: Dordrecht ; New York : Springer, ©2012.
叢書: Current topics in microbiology and immunology, v. 362.
版本/格式:   電子書 : 文獻 : 英語所有版本和格式的總覽
提要:
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of  再讀一些...
評定級別:

(尚未評分) 0 附有評論 - 成爲第一個。

主題
更多類似這樣的

 

在線上查詢

與資料的連結

在圖書館查詢

&AllPage.SpinnerRetrieving; 正在查詢有此資料的圖書館...

詳細書目

類型/形式: Electronic books
其他的實體格式: Print version:
Phosphoinositides and disease.
(DLC) 2012950382
(OCoLC)819537111
資料類型: 文獻, 網際網路資源
文件類型 網際網路資源, 電腦檔案
所有的作者/貢獻者: Marco Falasca
ISBN: 9789400750258 9400750250 9400794266 9789400794269
OCLC系統控制編碼: 817799592
語言註釋: English.
描述: 1 online resource (vi, 318 pages) : illustrations.
内容: Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles. Bisphosphates: Phosphatidylinositol 4,5-bisphosphateKinases; Phosphatases; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,4-bisphosphate; Kinases; Phosphatases; Other Routes of PtdIns(3,4)P2 Turnover; Intracellular Roles; Human Disease; Bisphosphates: Phosphatidylinositol 3,5-bisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Phosphatidylinositol 3,4,5-trisphosphate; Kinases; Phosphatases; Intracellular Roles; Human Disease; Conclusion; Acknowledgments; References; 2 Phosphoinositides and Cardiovascular Diseases; Abstract; Introduction. AtherosclerosisPIP3; IP3; Hypertrophy and Heart Failure; PIP3; IP3; PIP2; Arrhythmias; PIP2; IP3; PIP3; Conclusion; References; 3 Phosphoinositides in Insulin Action and Diabetes; Abstract; Introduction; The Synthesis and Degradation of Phosphoinositides; PI(3,4,5)P3 and PI(3,4)P2; PI(3)P; Regulation of PI(3,5)P2 and PI(5)P Levels; Metabolism of PI(4)P; Synthesis and Degradation of PI(4,5)P2; Relative Levels and Locations of Phosphoinositides; Acute Changes in Phosphoinositides; Phosphoinositides are Key Second Messengers in Insulin Action; Regulation of Akt Signaling Pathways. Regulation of mTORC1 SignalingPhosphoinositides Play Key Roles Downstream of Early Signaling in Insulin Action; GLUT4 Trafficking; Insulin Secretion; Glycogen and Lipid Synthesis; Genetics and Pharmacology of Phosphoinositide Disruption; PI(3,4,5)P3 and PI(3,4)P2; Negative Regulators of PI(3,4,5)P3; Phosphoinositide-Metabolizing Enzymes as Drug Targets in Diabetes; Summary; Acknowledgments; References; 4 Phosphoinositides in Neuroexocytosis and Neuronal Diseases; Abstract; The Discovery of the Phosphoinositide Pathway and its Role in Exocytosis; Role of Phosphoinositides and Neuroexocytosis. Identification of Phosphoinositide EffectorsLinks to Neurodegenerative Disease; Acknowledgments; References; 5 Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function; Abstract; Physical Properties of Phospholipids Affecting Membrane Morphology and Fusion; Acute and Inducible Modification of Lipids in Endomembranes; Role of Phosphoinositides and DAG on Endomembrane Function and Morphology; Phosphoinositides Associated with the Nucleus; Acknowledgments; References; 6 Molecular Analysis of Protein --
Phosphoinositide Interactions; Abstract; Introduction.
叢書名: Current topics in microbiology and immunology, v. 362.
責任: Marco Falasca, editor.

摘要:

This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when  再讀一些...

評論

讀者提供的評論
正在擷取GoodReads評論...
正在擷取DOGObooks的評論

標籤

成爲第一個
確認申請

你可能已經申請過這份資料。若還是想申請,請選確認。

連結資料


Primary Entity

<http://www.worldcat.org/oclc/817799592> # Phosphoinositides and disease
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "817799592" ;
    library:placeOfPublication <http://dbpedia.org/resource/New_York_City> ; # New York
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1184406615#Place/dordrecht> ; # Dordrecht
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/ne> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/cell_physiological_phenomena> ; # Cell Physiological Phenomena
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/biochemical_phenomena> ; # Biochemical Phenomena
    schema:about <http://id.loc.gov/authorities/subjects/sh89002397> ; # Cellular signal transduction
    schema:about <http://dewey.info/class/572.57/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/signal_transduction> ; # Signal Transduction
    schema:about <http://id.worldcat.org/fast/850288> ; # Cellular signal transduction
    schema:about <http://id.worldcat.org/fast/1054980> ; # Pathology, Molecular
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phenomena_and_processes> ; # Phenomena and Processes
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol_phosphates> ; # Inositol Phosphates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/sugar_phosphates> ; # Sugar Phosphates
    schema:about <http://id.loc.gov/authorities/subjects/sh85101107> ; # Phosphoinositides
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidic_acids> ; # Phosphatidic Acids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemicals_and_drugs> ; # Chemicals and Drugs
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidylinositols> ; # Phosphatidylinositols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phospholipids> ; # Phospholipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/sugar_alcohols> ; # Sugar Alcohols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophosphates> ; # Glycerophosphates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphoinositides_pathophysiology> ; # Phosphoinositides--Pathophysiology
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/membrane_lipids> ; # Membrane Lipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophospholipids> ; # Glycerophospholipids
    schema:about <http://id.loc.gov/authorities/subjects/sh85098691> ; # Pathology, Molecular
    schema:about <http://id.worldcat.org/fast/1061408> ; # Phosphoinositides
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/organic_chemicals> ; # Organic Chemicals
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemical_phenomena> ; # Chemical Phenomena
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/carbohydrates> ; # Carbohydrates
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/lipids> ; # Lipids
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/alcohols> ; # Alcohols
    schema:about <http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol> ; # Inositol
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/278055514> ; # Marco Falasca
    schema:copyrightYear "2012" ;
    schema:datePublished "2012" ;
    schema:description "Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated."@en ;
    schema:description "Phosphoinositidesand Disease; Contents; 1 An Introduction to Phosphoinositides; Abstract; The Phosphoinositide Family; Mechanisms of PIs-dependent Cellular Signalling; PIs-Binding Domains; Monophosphates: Phosphatidylinositol 3-phosphate; Kinases; Phosphatases; Other Routes of PtdIns3P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 4-phosphate; Kinases; Phosphatases; Other Routes of PtdIns4P Turnover; Intracellular Roles; Human Disease; Monophosphates: Phosphatidylinositol 5-phosphate; Kinases; Phosphatases; Intracellular Roles."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/1184406615> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/1184406615#Series/current_topics_in_microbiology_and_immunology> ; # Current topics in microbiology and immunology ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/819537111> ;
    schema:name "Phosphoinositides and disease"@en ;
    schema:productID "817799592" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/817799592#PublicationEvent/dordrecht_new_york_springer_2012> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1184406615#Agent/springer> ; # Springer
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=511420> ;
    schema:url <http://dx.doi.org/10.1007/978-94-007-5025-8> ;
    schema:url <http://swbplus.bsz-bw.de/bsz431236240cov.htm> ;
    schema:url <http://link.springer.com/openurl?genre=book&isbn=978-94-007-5024-1> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=1030745> ;
    schema:url <http://site.ebrary.com/id/10617886> ;
    schema:workExample <http://worldcat.org/isbn/9789400750258> ;
    schema:workExample <http://worldcat.org/isbn/9789400794269> ;
    schema:workExample <http://dx.doi.org/10.1007/978-94-007-5025-8> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/817799592> ;
    .


Related Entities

<http://dbpedia.org/resource/New_York_City> # New York
    a schema:Place ;
    schema:name "New York" ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Series/current_topics_in_microbiology_and_immunology> # Current topics in microbiology and immunology ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/817799592> ; # Phosphoinositides and disease
    schema:name "Current topics in microbiology and immunology ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/biochemical_phenomena> # Biochemical Phenomena
    a schema:Intangible ;
    schema:name "Biochemical Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/cell_physiological_phenomena> # Cell Physiological Phenomena
    a schema:Intangible ;
    schema:name "Cell Physiological Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemical_phenomena> # Chemical Phenomena
    a schema:Intangible ;
    schema:name "Chemical Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/chemicals_and_drugs> # Chemicals and Drugs
    a schema:Intangible ;
    schema:name "Chemicals and Drugs"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophosphates> # Glycerophosphates
    a schema:Intangible ;
    schema:name "Glycerophosphates"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/glycerophospholipids> # Glycerophospholipids
    a schema:Intangible ;
    schema:name "Glycerophospholipids"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/inositol_phosphates> # Inositol Phosphates
    a schema:Intangible ;
    schema:name "Inositol Phosphates"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/organic_chemicals> # Organic Chemicals
    a schema:Intangible ;
    schema:name "Organic Chemicals"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phenomena_and_processes> # Phenomena and Processes
    a schema:Intangible ;
    schema:name "Phenomena and Processes"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidic_acids> # Phosphatidic Acids
    a schema:Intangible ;
    schema:name "Phosphatidic Acids"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphatidylinositols> # Phosphatidylinositols
    a schema:Intangible ;
    schema:name "Phosphatidylinositols"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/phosphoinositides_pathophysiology> # Phosphoinositides--Pathophysiology
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh85101107> ; # Phosphoinositides
    schema:name "Phosphoinositides--Pathophysiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1184406615#Topic/signal_transduction> # Signal Transduction
    a schema:Intangible ;
    schema:name "Signal Transduction"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85098691> # Pathology, Molecular
    a schema:Intangible ;
    schema:name "Pathology, Molecular"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85101107> # Phosphoinositides
    a schema:Intangible ;
    schema:name "Phosphoinositides"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh89002397> # Cellular signal transduction
    a schema:Intangible ;
    schema:name "Cellular signal transduction"@en ;
    .

<http://id.worldcat.org/fast/1054980> # Pathology, Molecular
    a schema:Intangible ;
    schema:name "Pathology, Molecular"@en ;
    .

<http://id.worldcat.org/fast/1061408> # Phosphoinositides
    a schema:Intangible ;
    schema:name "Phosphoinositides"@en ;
    .

<http://id.worldcat.org/fast/850288> # Cellular signal transduction
    a schema:Intangible ;
    schema:name "Cellular signal transduction"@en ;
    .

<http://viaf.org/viaf/278055514> # Marco Falasca
    a schema:Person ;
    schema:familyName "Falasca" ;
    schema:givenName "Marco" ;
    schema:name "Marco Falasca" ;
    .

<http://worldcat.org/isbn/9789400750258>
    a schema:ProductModel ;
    schema:isbn "9400750250" ;
    schema:isbn "9789400750258" ;
    .

<http://worldcat.org/isbn/9789400794269>
    a schema:ProductModel ;
    schema:isbn "9400794266" ;
    schema:isbn "9789400794269" ;
    .

<http://www.worldcat.org/oclc/819537111>
    a schema:CreativeWork ;
    rdfs:label "Phosphoinositides and disease." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/817799592> ; # Phosphoinositides and disease
    .


Content-negotiable representations

關閉視窗

請登入WorldCat 

没有帳號嗎?你可很容易的 建立免費的帳號.