zum Inhalt wechseln
The physicochemical basis of pharmaceuticals
SchließenTitelvorschau

The physicochemical basis of pharmaceuticals

Verfasser/in: Humphrey A Moynihan; Abina M Crean
Verlag: Oxford ; New York : Oxford University Press, 2009.
Ausgabe/Format  Buch : EnglischAlle Ausgaben und Formate anzeigen
Inhaltsangabe:
"The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these  Weiterlesen…
Bewertung:

(noch nicht bewertet) 0 mit Rezensionen - Verfassen Sie als Erste eine Rezension.

 

Online anzeigen

Links zu diesem Titel

Exemplar ausleihen

Suchen… Suche nach Bibliotheken, die diesen Titel besitzen ...

Details

Gattung/Form: Textbooks
Medientyp: Internetquelle
Dokumenttyp: Buch, Internet-Ressource
Alle Autoren: Humphrey A Moynihan; Abina M Crean
ISBN: 9780199232840 0199232849
OCLC-Nummer: 277068140
Beschreibung: xv, 296 p. : ill. (some col.) ; 25 cm.
Inhalt: 1. PHARMACEUTICALS AND MEDICINES ; 1.1 Introduction to the essential properties of pharmaceuticals ; 1.1.1 Some key concepts ; 1.2 Classes of pharmaceutical compounds ; 1.2.1 Active pharmaceutical ingredients ; 1.2.2 Excipients ; 1.3 Drug delivery: getting the active pharmaceutical ingredient to the site of action ; 1.3.1 Routes of administration ; 1.3.2 Pharmaceutical dosage forms ; 1.3.3 Factors influencing dosage form choice ; 1.4 Summary ; 2. PHARMACEUTICAL SOLUTIONS ; 2.2 Definitions and expressions of solubility ; 2.1.1 Measurement of solubility and solubility curves ; 2.2 Solvent structure ; 2.2.1 Hydrogen bonding and the structure of water ; 2.2.2 Lipid-based media ; 2.3 Dissolution and solvation ; 2.4 Factors affecting solubility ; 2.4.1 Molecular weight ; 2.4.2 Hydrogen bonding ; 2.4.3 Hydrophobic and hydrophilic groups ; 2.5 Acidity and basicity ; 2.5.1 pKa and pKb ; 2.5.2 Acidity and environment ; 2.6 Salt selection and formation ; 2.7 Hydrolytic degradation ; 2.8 Summary ; 3. PHARMACEUTICAL EQUILIBRIA ; 3.1 Essential concepts in thermodynamics ; 3.1.1 Internal energy, enthalpy and the first law of thermodynamics ; 3.1.2 Entropy and the second and third laws of thermodynamics ; 3.1.3 Free energy, chemical potential and equilibrium ; 3.1.4 Activities of ions in solution ; 3.2 Phase equilibria ; 3.2.1 One-component systems and the phase rule ; 3.2.2 Two-component systems ; 3.2.3 Osmotic pressure ; 3.3 Drug delivery: Phase transitions ; 3.3.1 Diffusion (movement within a phase) ; 3.3.2 Dissolution (solid -liquid transition) ; 3.3.3 Partitioning (liquid- liquid transition) ; 3.3.4 Gas absorption (Gas-liquid phase transition) ; 3.3.5 Phase transitions during drug delivery ; 3.4 Summary ; 4. THE PHARMACEUTICAL SOLID PHASE ; 4.1 Crystalline and amorphous solids ; 4.2 The essentials of pharmaceutical crystal structure ; 4.2.1 Unit cells, crystal systems and lattices ; 4.2.2 Space groups and space group notation ; 4.2.3 Crystal planes and faces ; 4.3 Crystal polymorphism of pharmaceuticals ; 4.3.1 Relative stabilities of polymorphs ; 4.3.2 Solvates and hydrates ; 4.4 Methods of characterising pharmaceutical solids ; 4.4.1 X-ray diffraction methods ; 4.4.2 Thermal methods ; 4.4.3 Other methods of analysis ; 4.5 Pharmaceutical crystallization ; 4.5.1 Supersaturation ; 4.5.2 Nucleation, growth and crystal morphology ; 4.5.3 Ripening and the rule of stages ; 4.6 Solid state properties of powder particles ; 4.6.1 Particle shape ; 4.6.2 Particle size ; 4.6.3 Particle surface properties ; 4.6.4 Gas adsorption ; 4.6.5 Moisture adsorption ; 4.6.6 Powder mechanical strength ; 5. TWO PHASE SOLID - LIQUID DISPERSE SYSTEMS ; 5.1 Introduction to pharmaceutical disperse systems ; 5.2 Molecular, colloidal and coarse dispersions ; 5.3 The physical stability of disperse systems ; 5.4 Properties of disperse systems ; 5.4.1 Kinetic properties ; 5.4.2 Rheology and viscosity ; 5.4.3 Electrical properties ; 5.4.4 Interfacial properties ; 5.4.5 Optical properties ; 5.5 Suspensions ; 5.5.1 Nanosuspensions ; 5.5.2 Coarse suspensions ; 5.6 Emulsions ; 5.6.1 Macroemulsions ; 5.6.2 Multiple emulsions ; 5.6.3 Microemulsions ; 5.7 Vesicular systems ; 5.7.1 Micellar systems ; 5.7.2 Solubilised systems ; 5.7.3 Liposomes ; 5.8 Aerosols ; 5.9 Foams ; 5.10 Summary ; 6. BIOLOGICAL INTERFACES ; 6.1 Passive, active and other modes of transport ; 6.2 Cell membranes ; 6.3 Partition and partition co-efficients ; 6.4 Measurement and calculation of partition co-efficients ; 6.5 Diffusion, diffusion co-efficients and ionisation ; 6.6 The gastrointestinal barrier ; 6.7 The blood-brain barrier ; 6.8 The skin ; 6.9 Summary ; 7. PHYSICOCHEMICAL ASPECTS OF PHARMACOKINETICS AND PHARMACODYNAMICS ; 7.1 Bioavailability ; 7.2 Distribution ; 7.3 Drug target interaction ; 7.4 Metabolism ; 7.5 Excretion ; 7.6 Summary
Verfasserangabe: Humphrey A. Moynihan, Abina M. Crean.
Weitere Informationen:

Abstract:

The Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible  Weiterlesen…

Rezensionen

Nutzer-Rezensionen

Tags

Alle Nutzer-Tags (1)

Anzeige der beliebtesten Schlagwörter als: Schlagwortliste | Tag Cloud

Ähnliche Titel

Verwandte Themen:(6)

Nutzerlisten mit diesen Titeln (1)

Anfrage bestätigen

Sie haben diesen Titel bereits angefordert. Wenn Sie trotzdem fortfahren möchten, klicken Sie auf OK.

Verlinkung


<http://www.worldcat.org/oclc/277068140>
library:oclcnum"277068140"
library:placeOfPublication
library:placeOfPublication
library:placeOfPublication
owl:sameAs<info:oclcnum/277068140>
rdf:typeschema:Book
rdfs:seeAlso
rdfs:seeAlso
schema:about
rdf:typeschema:Intangible
schema:name"Pharmaceutical Preparations--chemistry."
schema:about
schema:about
schema:about
rdf:typeschema:Intangible
schema:name"Chimie pharmaceutique."
schema:about
rdf:typeschema:Intangible
schema:name"Chemistry, Pharmaceutical--methods."
schema:about
schema:author
schema:contributor
schema:datePublished"2009"
schema:genre"Textbooks"
schema:inLanguage"en"
schema:name"The physicochemical basis of pharmaceuticals"
schema:numberOfPages"296"
schema:publisher
schema:reviews
rdf:typeschema:Review
schema:itemReviewed<http://www.worldcat.org/oclc/277068140>
schema:reviewBody""The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these concepts apply in practice." "The book introduces key underlying physical chemistry principles before exploring pharmaceutical solutions, the pharmaceutical solid phase, solid - liquid dispersal systems, biological interfaces, absorption, distribution, metabolism and excretion, to give a complete view of the field." "The Physicochemical Basis of Pharmaceuticals avoids excessive detail, presenting the key facts, backed up with pertinent examples and easy-to-digest illustrations, making it the ideal primer for those who need to understand physicochemical issues in the context of their broader field of study."--BOOK JACKET."
umbel:isLike<http://bnb.data.bl.uk/id/resource/014-84462>
umbel:isLike<http://bnb.data.bl.uk/id/resource/GBA-8D622>
umbel:isLike<http://bnb.data.bl.uk/id/resource/GBA8D6222>
Fenster schließen

Bitte in WorldCat einloggen 

Sie haben kein Konto? Sie können sehr einfach ein kostenloses Konto anlegen,.

Abbrechen Passwort vergessen?