pular para conteúdo
The physicochemical basis of pharmaceuticals Ver prévia deste item
FecharVer prévia deste item
Checando...

The physicochemical basis of pharmaceuticals

Autor: Humphrey A Moynihan; Abina M Crean
Editora: Oxford ; New York : Oxford University Press, 2009.
Edição/Formato   Livro : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
"The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these  Ler mais...
Classificação:

(ainda não classificado) 0 com críticas - Seja o primeiro.

Assuntos
Mais como este

 

Encontrar uma cópia on-line

Links para este item

Encontrar uma cópia na biblioteca

&AllPage.SpinnerRetrieving; Encontrando bibliotecas que possuem este item...

Detalhes

Gênero/Forma: Textbooks
Tipo de Material: Recurso Internet
Tipo de Documento: Livro, Recurso Internet
Todos os Autores / Contribuintes: Humphrey A Moynihan; Abina M Crean
ISBN: 9780199232840 0199232849
Número OCLC: 277068140
Descrição: xv, 296 p. : ill. (some col.) ; 25 cm.
Conteúdos: 1. PHARMACEUTICALS AND MEDICINES ; 1.1 Introduction to the essential properties of pharmaceuticals ; 1.1.1 Some key concepts ; 1.2 Classes of pharmaceutical compounds ; 1.2.1 Active pharmaceutical ingredients ; 1.2.2 Excipients ; 1.3 Drug delivery: getting the active pharmaceutical ingredient to the site of action ; 1.3.1 Routes of administration ; 1.3.2 Pharmaceutical dosage forms ; 1.3.3 Factors influencing dosage form choice ; 1.4 Summary ; 2. PHARMACEUTICAL SOLUTIONS ; 2.2 Definitions and expressions of solubility ; 2.1.1 Measurement of solubility and solubility curves ; 2.2 Solvent structure ; 2.2.1 Hydrogen bonding and the structure of water ; 2.2.2 Lipid-based media ; 2.3 Dissolution and solvation ; 2.4 Factors affecting solubility ; 2.4.1 Molecular weight ; 2.4.2 Hydrogen bonding ; 2.4.3 Hydrophobic and hydrophilic groups ; 2.5 Acidity and basicity ; 2.5.1 pKa and pKb ; 2.5.2 Acidity and environment ; 2.6 Salt selection and formation ; 2.7 Hydrolytic degradation ; 2.8 Summary ; 3. PHARMACEUTICAL EQUILIBRIA ; 3.1 Essential concepts in thermodynamics ; 3.1.1 Internal energy, enthalpy and the first law of thermodynamics ; 3.1.2 Entropy and the second and third laws of thermodynamics ; 3.1.3 Free energy, chemical potential and equilibrium ; 3.1.4 Activities of ions in solution ; 3.2 Phase equilibria ; 3.2.1 One-component systems and the phase rule ; 3.2.2 Two-component systems ; 3.2.3 Osmotic pressure ; 3.3 Drug delivery: Phase transitions ; 3.3.1 Diffusion (movement within a phase) ; 3.3.2 Dissolution (solid -liquid transition) ; 3.3.3 Partitioning (liquid- liquid transition) ; 3.3.4 Gas absorption (Gas-liquid phase transition) ; 3.3.5 Phase transitions during drug delivery ; 3.4 Summary ; 4. THE PHARMACEUTICAL SOLID PHASE ; 4.1 Crystalline and amorphous solids ; 4.2 The essentials of pharmaceutical crystal structure ; 4.2.1 Unit cells, crystal systems and lattices ; 4.2.2 Space groups and space group notation ; 4.2.3 Crystal planes and faces ; 4.3 Crystal polymorphism of pharmaceuticals ; 4.3.1 Relative stabilities of polymorphs ; 4.3.2 Solvates and hydrates ; 4.4 Methods of characterising pharmaceutical solids ; 4.4.1 X-ray diffraction methods ; 4.4.2 Thermal methods ; 4.4.3 Other methods of analysis ; 4.5 Pharmaceutical crystallization ; 4.5.1 Supersaturation ; 4.5.2 Nucleation, growth and crystal morphology ; 4.5.3 Ripening and the rule of stages ; 4.6 Solid state properties of powder particles ; 4.6.1 Particle shape ; 4.6.2 Particle size ; 4.6.3 Particle surface properties ; 4.6.4 Gas adsorption ; 4.6.5 Moisture adsorption ; 4.6.6 Powder mechanical strength ; 5. TWO PHASE SOLID - LIQUID DISPERSE SYSTEMS ; 5.1 Introduction to pharmaceutical disperse systems ; 5.2 Molecular, colloidal and coarse dispersions ; 5.3 The physical stability of disperse systems ; 5.4 Properties of disperse systems ; 5.4.1 Kinetic properties ; 5.4.2 Rheology and viscosity ; 5.4.3 Electrical properties ; 5.4.4 Interfacial properties ; 5.4.5 Optical properties ; 5.5 Suspensions ; 5.5.1 Nanosuspensions ; 5.5.2 Coarse suspensions ; 5.6 Emulsions ; 5.6.1 Macroemulsions ; 5.6.2 Multiple emulsions ; 5.6.3 Microemulsions ; 5.7 Vesicular systems ; 5.7.1 Micellar systems ; 5.7.2 Solubilised systems ; 5.7.3 Liposomes ; 5.8 Aerosols ; 5.9 Foams ; 5.10 Summary ; 6. BIOLOGICAL INTERFACES ; 6.1 Passive, active and other modes of transport ; 6.2 Cell membranes ; 6.3 Partition and partition co-efficients ; 6.4 Measurement and calculation of partition co-efficients ; 6.5 Diffusion, diffusion co-efficients and ionisation ; 6.6 The gastrointestinal barrier ; 6.7 The blood-brain barrier ; 6.8 The skin ; 6.9 Summary ; 7. PHYSICOCHEMICAL ASPECTS OF PHARMACOKINETICS AND PHARMACODYNAMICS ; 7.1 Bioavailability ; 7.2 Distribution ; 7.3 Drug target interaction ; 7.4 Metabolism ; 7.5 Excretion ; 7.6 Summary
Responsabilidade: Humphrey A. Moynihan, Abina M. Crean.
Mais informações:

Resumo:

The Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible  Ler mais...

Críticas

Críticas contribuídas por usuários
Recuperando críticas GoodReas...
Recuperando comentários DOGObooks

Etiquetas

Etiquetas de todos os usuários (1)

Ver as etiquetas mais populares como: lista de etiquetas | nuvem de etiquetas

Confirmar esta solicitação

Você já pode ter solicitado este item. Por favor, selecione Ok se gostaria de proceder com esta solicitação de qualquer forma.

Dados Ligados


<http://www.worldcat.org/oclc/277068140>
library:oclcnum"277068140"
library:placeOfPublication
library:placeOfPublication
library:placeOfPublication
rdf:typeschema:Book
rdf:typeschema:MediaObject
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:contributor
schema:creator
schema:datePublished"2009"
schema:exampleOfWork<http://worldcat.org/entity/work/id/159799378>
schema:genre"Textbooks"@en
schema:inLanguage"en"
schema:name"The physicochemical basis of pharmaceuticals"@en
schema:numberOfPages"296"
schema:publication
schema:publisher
schema:reviews
rdf:typeschema:Review
schema:itemReviewed<http://www.worldcat.org/oclc/277068140>
schema:reviewBody""The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these concepts apply in practice." "The book introduces key underlying physical chemistry principles before exploring pharmaceutical solutions, the pharmaceutical solid phase, solid - liquid dispersal systems, biological interfaces, absorption, distribution, metabolism and excretion, to give a complete view of the field." "The Physicochemical Basis of Pharmaceuticals avoids excessive detail, presenting the key facts, backed up with pertinent examples and easy-to-digest illustrations, making it the ideal primer for those who need to understand physicochemical issues in the context of their broader field of study."--BOOK JACKET."
schema:workExample
umbel:isLike<http://bnb.data.bl.uk/id/resource/014-84462>
umbel:isLike<http://bnb.data.bl.uk/id/resource/GBA-8D622>
umbel:isLike<http://bnb.data.bl.uk/id/resource/GBA8D6222>
wdrs:describedby

Content-negotiable representations

Close Window

Por favor, conecte-se ao WorldCat 

Não tem uma conta? Você pode facilmente criar uma conta gratuita.