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Physiological functions of cytochrome P450 in relation to structure and regulation

Author: E E Bittar; Colin R Jeffcoate
Publisher: Greenwich, Conn. : JAI Press, 1996.
Series: Advances in molecular and cell biology, v. 14.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Research on the cytochrome P450 family of genes has traditionally been dominated by forms participating in drug metabolism. This has occurred in spite of early discovery of steroid hydroxy lase P450 cytochromes in the adrenal gland. More recently, contributions on the characterization and regulation of P450 cytochromes involved in biosynthetic reactions have been found at the international meetings on cytochrome  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: E E Bittar; Colin R Jeffcoate
ISBN: 0762301139 9780762301133
OCLC Number: 464825523
Description: 1 online resource (xii, 379 pages) : illustrations.
Contents: Contents. List of Contributors. Preface (C.R. Jefcoate). P450 Cytochromes and Hormonal Regulation: An Overview (C.R. Jefcoate). Electron Transfer Proteins of Cytochrome P450 Systems (I. Hanukoglu). The Molecular Structure of P450s: The Conserved and the Variable Elements (S.E. Graham-Lorence and J.A. Peterson). Diverse Molecular Mechanisms Regulate the Expression of Steroid Hydryxylase Genes Required for Production of Ligands for Nuclear Receptors (M.R. Waterman and D.S. Keeney). Cytochrome P450scc and Regulation of Cholesterol Conversion to Steroid Hormones (C.R. Jefacoate). The Regulation of the Formation of Glucocorticoids and Mineralocorticoids In Vivo (J. LeHoux, H. Bernard, L. Ducharme, A. Lefebvre, D. Shapcott, A. Tremblay, and S. Veronneau). Physiology and Molecular Biology of P450c21 and P450c17 (B. Chung). The Aromatase Reaction (E.R. Simpson, M.S. Mahendroo, M.W. Kilgore, G.D. Means, S.E. Bulun, M.M. Hinshelwood, and C.R. Mendelson). Regulation of Calcium Metabolism by the Vitamin D Hydroxylases (H.J. Armbrecht, R.K. Nemani, and N. Wongsurawat). The Regulation of Cholesterol Conversion to Bile Acids (J.Y.L. Chiang and Z.R. Vlahcevic). Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450 (J.H. Capdevila, D. Zeldin, A. Karara, and J.R. Falck). Steroid Hormones and Other Physiologic Regulators of Liver Cytochromes P450: Metabolic Reactions and Regulatory Pathways (D.J. Waxman). Index.
Series Title: Advances in molecular and cell biology, v. 14.
Responsibility: Series ed. E. Edward Bittar ; Guest ed. Colin R. Jefcoate.

Abstract:

Research on the cytochrome P450 family of genes has traditionally been dominated by forms participating in drug metabolism. This book focuses on the physiological processes that are controlled by the  Read more...

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