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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry

Author: Sheila Annie Peters
Publisher: Hoboken, N.J. : Wiley, ©2011.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(DLC) 2011019939
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sheila Annie Peters
ISBN: 0470484063 9780470484067 9781280588631 1280588632 9781118140291 111814029X 9781118140383 1118140389
OCLC Number: 794619804
Description: 1 online resource (pages)
Contents: Modelling in the pharmaceutical industry --
Physiologically-based modelling --
A review of pharmacokinetic principles --
Physiological model for absorption --
Physiological model for distribution --
Physiological models for drug metabolism and excretion --
Generic whole-body physiologically-based pharmacokinetic modelling --
Variability, uncertainty and sensitivity analysis --
Evaluation of drug-drug interaction risk with pbpk models --
PBPK of biotherapeutics --
Data integration and sensitivity analysis --
Hypothesis generation and pharmacokinetic predictions --
Integration of PBPK and pharmacodynamics --
PBPK modelling of populations --
PBPK models along the drug discovery and development value chain.
Responsibility: Sheila Annie Peters.
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Abstract:

This book describes the principles, methods, and applications of PBPK modeling in the pharmaceutical industry. It addresses a growing need, as more and more pharma companies are integrating PBPK into  Read more...

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There is little to fault the book. ... [it] should be on the shelf and a companion to anyone seriously interested in mechanistic model-based drug development. (Nature CPT, 10 July 2013) Peters does a Read more...

 
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