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|Material Type:||Clipart/images/graphics, Internet resource, Videorecording|
|Document Type:||Internet Resource, Computer File, Visual material|
|All Authors / Contributors:||
|Notes:||Animated audio-visual presentation with synchonized narration.
Title from title frames.
|Description:||1 streaming video file (25 min.).|
|Contents:||Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection --
This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes --
Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them --
In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling --
Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
|Series Title:||Henry Stewart talks., Biomedical & life sciences collection., Innate immunity : host recognition and response in health and disease.|