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Plasmacytoid dendritic cells : sensing nucleic acids in viral infection and autoimmunity

Author: Yong-Jun Liu
Publisher: London : Henry Stewart Talks, 2009.
Series: Henry Stewart talks., Biomedical & life sciences collection., Innate immunity : host recognition and response in health and disease.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
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Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Yong-Jun Liu
OCLC Number: 466339409
Notes: Animated audio-visual presentation with synchonized narration.
Title from title frames.
Description: 1 streaming video file (25 min.).
Contents: Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection --
This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes --
Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them --
In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling --
Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Innate immunity : host recognition and response in health and disease.
Responsibility: Yong-Jun Liu.
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