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Platelet protocols : research and clinical laboratory procedures

Author: Melanie McCabe White; Lisa K Jennings
Publisher: San Diego : Academic Press, ©1999.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery,  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Additional Physical Format: Print version:
White, Melanie McCabe.
Platelet protocols.
San Diego : Academic Press, ©1999
(DLC) 98083126
(OCoLC)41067860
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Melanie McCabe White; Lisa K Jennings
ISBN: 9780123842602 0123842603 9781435605008 1435605004 0080539122 9780080539126
OCLC Number: 162128932
Description: 1 online resource (xi, 116 pages, [1] leaf of plates) : illustrations (some color)
Contents: Basic Introduction to Platelets: --
Introduction. --
Platelets in Hemostasis. --
Membrane Surface Proteins. --
Events Associated with Platelet Aggregation. --
Agonists. --
Coagulation. --
Laboratory Evaluation of Platelet Function: --
Introduction. --
Variables. --
Drawing and Processing Blood for Platelet Aggregation. --
Platelet Aggregation and Secretion. --
Platelet Agonists. --
Clot Retraction. --
Functional Abnormalities of Platelets: --
Introduction. --
Storage Pool Disorders. --
Release Defects. --
Glanzmann's Thrombasthenia. --
Von Willebrand's Disease. --
Bernard Soulier Syndrome. --
Bleeding Time Prolongation. --
Therapeutic Approaches to Inhibition of Platelet Function and Pharmacodynamic Evaluations: --
GPIIb-IIIa Antagonists. --
Other Anti-Platelet Therapies. --
Drugs That May Affect Platelet Function. --
Appendix: --
Recipes for Citrate Based Anticoagulants. --
Inhibitors Used in Platelet Techniques. --
Cytoskeletal Preparation and Recipes. --
Gel-Filtered Platelets. --
Washed Platelets. --
Western Blots of Acrylamide Gels Gell and Blot Recipes. --
Staining of Platelets for Flow Cytometric Analysis. --
Subject Index. Basic introduction to platelets --
Laboratory evaluation of platelet function --
Functional abnormalities of platelets --
Therapeutic approaches to inhibition of platelet function.
Responsibility: Melanie McCabe White and Lisa K. Jennings ; selected illustrations by Michael P. Condry.
More information:

Abstract:

Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. This manual includes procedures for evaluating and analyzing platelet function  Read more...

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