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Polymer drugs in the clinical stage : advantages and prospects

Author: H Maeda; Alexander V Kabanov
Publisher: Dordrecht ; London : Kluwer Academic/Plenum, 2003.
Series: Advances in experimental medicine and biology, v. 519.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
Second author, Alexander Kabanov, is with the Univ. of Nebraska, Omaha. Text presents monographs presented at the International Symposium of Polymer Therapeutics - Recent Progress in Clinic and Future Prospects, held in Nara, Japan, July 13-14, 2001. Discusses polymer drugs and their wide range of uses.
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Genre/Form: Conference papers and proceedings
Congresses
Congrès
Material Type: Conference publication, Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: H Maeda; Alexander V Kabanov
ISBN: 9780306474712 0306474719
OCLC Number: 51483510
Notes: "Proceedings of the International Symposium on Polymer Therapeutics--Recent Progress in Clinics and Future Prospects, held July 13-14, 2001, in Nara, Japan"--Title page verso.
Description: viii, 224 pages : illustrations ; 26 cm.
Contents: Challenges in polymer therapeutics: state of the art and prospects of polymer drugs --
Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS --
PEG-adenosine deaminase and PEG-asparaginase --
Peginterferon alfa-2a (40KD): a potent long-acting form of interferon alfa-2a for the treatment of hepatitis C --
PEG-methioninase --
Poly-(L)-glutamic acid-paclitaxel (CT-2103)[XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data --
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer --
Drug-HPMA-HuIg conjugates effective against human solid cancer --
CM-dextran-polyalcohol-camptothecin conjugate: DE310 with a novel carrier system and its preclinical data --
Polymeric micelle drug carrier systems: PEG-PAsp(Dox) and second generation of micellar drugs --
Interim analysis of phase I clinical trial of MCC-465, a doxorubicin (DXR) encapsulated in PEG-immunoliposome, in patients with metastatic stomach cancer --
Polymer conjugates for imaging --
S-Nitrosylated polyethylene glycol-conjugated hemoglobin derivative as a candidate material for oxygen therapeutics.
Series Title: Advances in experimental medicine and biology, v. 519.
Responsibility: edited by Hiroshi Maeda and Alexander Kabanov.
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Abstract:

Cancer targeted drug delivery is another focused area of this volume because of the important nature of EPR-effect of polymer drugs in tumor. The concept of "Polymer drugs" here is limited to  Read more...

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