skip to content
The practice of medicinal chemistry Preview this item
ClosePreview this item
Checking...

The practice of medicinal chemistry

Author: C G Wermuth; David Aldous; Pierre Raboisson; Didier Rognan
Publisher: London, UK : Academic Press, 2015.
Edition/Format:   eBook : Document : English : Fourth editionView all editions and formats
Summary:
The Practice of Medicinal Chemistry, Fourth Edition, provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough and excellent treatment of basic medicinal chemistry principles, this updated edition has been thoroughly revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Wermuth, Camille Georges.
Practice of Medicinal Chemistry.
Burlington : Elsevier Science, ©2015
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: C G Wermuth; David Aldous; Pierre Raboisson; Didier Rognan
ISBN: 9780124172135 012417213X 0124172059
OCLC Number: 913530203
Notes: Includes index.
Description: 1 online resource
Contents: Front Cover; The Practice of Medicinal Chemistry; Copyright Page; Contents; List of Contributors; Foreword; Preface to the Fourth Edition; Preface to the Third Edition; Preface to the Second Edition; Preface to the First Edition; I. General Aspects of Medicinal Chemistry; 1 Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems; I. Definitions and Objectives; A Medicinal Chemistry and Related Disciplines and Terms; B Drugs and Drug Substances; C Stages of Drug Development; II. Drug Activity Phases; A The Pharmaceutical Phase. B The Pharmacokinetic PhaseC The Pharmacodynamic Phase; D The Road to Successful Drug Development?; III. Drug Classification Systems; A Classification by Target and Mechanism of Action; 1 Targets; 2 Mechanisms of Action; B Other Classification Systems; References; 2 Evaluation of the Biological Activity of Compounds: Techniques and Mechanism of Action Studies; I. Introduction; II. Drug Discovery Approaches and Screening Cascades; A Target Based Screening; B Phenotypic Screening; III. In Vitro Assays; A Primary Assays; Glossary; 1 Binding assays; 2 Binding Studies: Principles and Analysis. 3 Enzyme Assays4 Types of Enzyme Inhibition and Their Analysis; A Reversible Inhibitors; B Irreversible Inhibitors; C Competitive Inhibitors; D Noncompetitive Inhibitors; E Uncompetitive Inhibitors; 5 Functional Assays; 6 Functional Studies and Their Analysis; A Agonist Concentration-Effect (E/[A]) Curves; B Full Agonists, Partial Agonists, and Inverse Agonists; C Optimizing Agonists; D Analysis of Antagonists; Competitive Antagonists; Irreversible, Noncompetitive, and Allosteric Antagonists; B Compound Interference in Primary Assays: Artifacts and False Positives; C Assay Biostatistics. D Selectivity, Cytotoxicity, and Species Cross-over. 1 Selectivity; 2 Cytotoxicity; 3 Species Crossover; E Cellular and Tissue Functional Responses; IV. Ex Vivo Assays; V. In Vivo Assays; A Pharmacokinetic Models; B Efficacy Models; C Safety Testing; Acknowledgements; References; 3 Drug Targets, Target Identification, Validation, and Screening; I. Introduction; II. What is a Drug Target?; III. The Purpose of Target Identification; A Target-Based Screening; B Phenotypic Screening; C Fast Follower Strategy; IV. Target Options and Treatment Options; V. Target Deconvolution and Target Discovery. VI. Methods for Target Identification and ValidationA Affinity Chromatography; B Genetic Methods; C Haploinsufficiency Profiling in Yeast; D Analysis of Resistant Mutants; E siRNA for Target Validation; F Yeast Three-Hybrid System; G DNA Microarrays; H Comparative Profiling; I Analysis of the Pathophysiology; J The Study of Existing Drugs; K Systems Biology; L In Silico Simulation of the Human Patient; VII. Target Validation; VIII. Conclusion; References; II. Lead Compound Discovery Strategies; 4 Strategies in the Search for New Lead Compounds or Original Working Hypotheses; I. Introduction.
Responsibility: edited by Camille Georges Wermuth, David Aldous, Pierre Raboisson, Didier Rognan.

Abstract:

The Practice of Medicinal Chemistry, Fourth Edition, provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough and excellent treatment of basic medicinal chemistry principles, this updated edition has been thoroughly revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With in-depth coverage of high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

Reviews

Editorial reviews

Publisher Synopsis

"Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process."- John L. Neumeyer, Harvard Medical School, Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(2)

User lists with this item (3)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/913530203> # The practice of medicinal chemistry
    a schema:Book, schema:CreativeWork, schema:MediaObject ;
    library:oclcnum "913530203" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/enk> ;
    schema:about <http://dewey.info/class/615.19/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/866133867#Topic/drugs_design> ; # Drugs--Design
    schema:about <http://experiment.worldcat.org/entity/work/data/866133867#Topic/pharmaceutical_chemistry> ; # Pharmaceutical chemistry
    schema:bookEdition "Fourth edition." ;
    schema:bookFormat schema:EBook ;
    schema:datePublished "2015" ;
    schema:description "The Practice of Medicinal Chemistry, Fourth Edition, provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough and excellent treatment of basic medicinal chemistry principles, this updated edition has been thoroughly revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With in-depth coverage of high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development."@en ;
    schema:description "Front Cover; The Practice of Medicinal Chemistry; Copyright Page; Contents; List of Contributors; Foreword; Preface to the Fourth Edition; Preface to the Third Edition; Preface to the Second Edition; Preface to the First Edition; I. General Aspects of Medicinal Chemistry; 1 Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems; I. Definitions and Objectives; A Medicinal Chemistry and Related Disciplines and Terms; B Drugs and Drug Substances; C Stages of Drug Development; II. Drug Activity Phases; A The Pharmaceutical Phase."@en ;
    schema:editor <http://experiment.worldcat.org/entity/work/data/866133867#Person/wermuth_c_g> ; # C. G. Wermuth
    schema:editor <http://experiment.worldcat.org/entity/work/data/866133867#Person/aldous_david_david_john> ; # David John Aldous
    schema:editor <http://experiment.worldcat.org/entity/work/data/866133867#Person/rognan_didier> ; # Didier Rognan
    schema:editor <http://experiment.worldcat.org/entity/work/data/866133867#Person/raboisson_pierre> ; # Pierre Raboisson
    schema:exampleOfWork <http://worldcat.org/entity/work/id/866133867> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://worldcat.org/entity/work/data/866133867#CreativeWork/practice_of_medicinal_chemistry> ;
    schema:name "The practice of medicinal chemistry"@en ;
    schema:productID "913530203" ;
    schema:url <http://site.ebrary.com/id/11071288> ;
    schema:url <http://app.knovel.com/hotlink/toc/id:kpPMCE0015/practice-of-medicinal> ;
    schema:url <http://www.sciencedirect.com/science/book/9780124172050> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=2079962> ;
    schema:workExample <http://worldcat.org/isbn/9780124172050> ;
    schema:workExample <http://worldcat.org/isbn/9780124172135> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/913530203> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/866133867#Person/aldous_david_david_john> # David John Aldous
    a schema:Person ;
    schema:familyName "Aldous" ;
    schema:givenName "David John" ;
    schema:givenName "David" ;
    schema:name "David John Aldous" ;
    .

<http://experiment.worldcat.org/entity/work/data/866133867#Person/raboisson_pierre> # Pierre Raboisson
    a schema:Person ;
    schema:familyName "Raboisson" ;
    schema:givenName "Pierre" ;
    schema:name "Pierre Raboisson" ;
    .

<http://experiment.worldcat.org/entity/work/data/866133867#Person/rognan_didier> # Didier Rognan
    a schema:Person ;
    schema:familyName "Rognan" ;
    schema:givenName "Didier" ;
    schema:name "Didier Rognan" ;
    .

<http://experiment.worldcat.org/entity/work/data/866133867#Person/wermuth_c_g> # C. G. Wermuth
    a schema:Person ;
    schema:familyName "Wermuth" ;
    schema:givenName "C. G." ;
    schema:name "C. G. Wermuth" ;
    .

<http://experiment.worldcat.org/entity/work/data/866133867#Topic/pharmaceutical_chemistry> # Pharmaceutical chemistry
    a schema:Intangible ;
    schema:name "Pharmaceutical chemistry"@en ;
    .

<http://worldcat.org/entity/work/data/866133867#CreativeWork/practice_of_medicinal_chemistry>
    a schema:CreativeWork ;
    rdfs:label "Practice of Medicinal Chemistry." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/913530203> ; # The practice of medicinal chemistry
    .

<http://worldcat.org/isbn/9780124172050>
    a schema:ProductModel ;
    schema:isbn "0124172059" ;
    schema:isbn "9780124172050" ;
    .

<http://worldcat.org/isbn/9780124172135>
    a schema:ProductModel ;
    schema:isbn "012417213X" ;
    schema:isbn "9780124172135" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.