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Precision molecular pathology of liver cancer

Author: Chen Liu
Publisher: Cham, Switzerland : Springer, 2018.
Series: Molecular pathology library series.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Chen Liu
ISBN: 9783319680828 331968082X
OCLC Number: 1018942593
Notes: Includes index.
Description: 1 online resource.
Contents: Intro; Preface; Contents; Contributors; 1: Etiology and Pathogenesis of Hepatocellular Carcinoma; 1.1 Introduction; 1.2 Etiology; 1.3 Virus-Induced Hepatocarcinogenesis; 1.3.1 HBV; 1.3.2 HCV; 1.4 NAFLD Cirrhosis-Induced Hepatocarcinogenesis; 1.5 Toxin-Mediated Hepatocarcinogenesis; 1.5.1 Alcohol Induced; 1.5.2 Aflatoxin-B1 Induced; 1.6 Common Themes; 1.7 Molecular Mechanisms; 1.7.1 Methylation; 1.7.2 MET and HGF; 1.7.3 ErbB Receptor Family; 1.7.4 B-Catenin; 1.7.5 p53 Tumor Suppression; References. 2: Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications2.1 Conventional Hepatocellular Carcinoma (HCC); 2.2 Small HCC; 2.3 Special Histologic Subtypes; 2.3.1 Fibrolamellar HCC; 2.3.2 Scirrhous HCC; 2.3.3 Steatohepatitic HCC; 2.3.4 Lymphoepithelioma-Like HCC (LEL-HCC); 2.3.5 Sarcomatoid HCC; 2.3.6 Undifferentiated Carcinoma; 2.3.7 Diffuse Cirrhosis-Like HCC (CL-HCC); 2.3.8 Combined Hepatocellular-Cholangiocarcinoma; 2.4 Grading and Staging; 2.4.1 Grading HCC; 2.4.2 Staging HCC; References. 3: Molecular Classification of Hepatocellular Carcinoma and Precision Medicine3.1 Introduction; 3.2 Molecular Alterations; 3.2.1 TERT; 3.2.2 Wnt/β-Catenin; 3.2.3 p53; 3.2.4 CDKN2A (p16); 3.2.5 AXIN1 and 2; 3.2.6 RAS; 3.2.7 MET; 3.2.8 TGFβ; 3.2.9 VEGFA; 3.2.10 EpCAM; 3.2.11 PTEN; 3.2.12 Epigenetic Alterations; 3.2.13 Chromosome Instability; 3.3 Molecular Classification; 3.3.1 Overview; 3.3.2 Proliferation Class; 3.3.3 Nonproliferation Class; References; 4: Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing. 4.1 Hepatocellular Carcinoma and Its Heterogeneity4.1.1 HCC Heterogeneity in Etiology; 4.1.2 HCC Heterogeneity in Clinical Presentation; 4.1.3 HCC Heterogeneity at the Biological Level; 4.2 Next-Generation Sequencing System; 4.2.1 Roche 454 Sequencing; 4.2.2 Illumina Sequencing; 4.2.3 SOLiD Sequencing; 4.2.4 Ion Personal Genome Machine; 4.2.5 The Third-Generation Sequencers; 4.3 HCC Genomics Studies via NGS Technology; 4.3.1 HCC Viral Risk Factors in Viral-Related HCCs; HBV Integration in HBV-Related HCCs; HCV Quasispecies Diversity in Chronic Liver Disease and HCC. 4.3.2 Mutational Landscapes in HCCWNT/Beta-Catenin Pathway and P53 Pathway; Chromatin Regulators; PI3K/Akt/mTOR-Pathway and MAPK Pathway; Others; 4.3.3 Expression Profiles of HCC; 4.3.4 Epigenetic Alterations in HCC; 4.3.5 Potential Clinical Utilization in HCC; 4.4 Conclusion and Prospective; References; 5: Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application; 5.1 Introduction; 5.2 Epigenetics; 5.2.1 DNA Methylation; 5.2.2 Micro RNAs; 5.2.3 Histone Modifications and Histone Variants; 5.3 Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Series Title: Molecular pathology library series.
Responsibility: Chen Liu, editor.

Abstract:

Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and  Read more...

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