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Preclinical development handbook. ADME and biopharmaceutical properties

Author: Shayne C Gad
Publisher: Hoboken, N.J. : Wiley-Interscience, ©2008.
Edition/Format:   Print book : EnglishView all editions and formats
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This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process  Read more...

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Genre/Form: Handbooks and manuals
Handbooks, manuals, etc
Guides, manuels, etc
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Shayne C Gad
ISBN: 9780470248478 0470248475
OCLC Number: 176895587
Description: xv, 1329 pages : illustrations ; 26 cm
Contents: Preface. 1 Modeling and Informatics in Drug Design ( Prasad V. Bharatam, Smriti Khanna, and Sandrea M. Francis ). 2 Computer Techniques: Identifying Similarities Between Small Molecules ( Peter Meek, Guillermo Moyna, and Randy Zauhar ). 3 Protein-Protein Interactions ( Kamaljit Kaur, Dipankar Das, and Mavanur R. Suresh ). 4 Method Development for Preclinical Bioanalytical Support ( Masood Khan and Naidong Weng ). 5 Analytical Chemistry Methods: Developments and Validation ( Izet M. Kapetanovic and Alexander V. Lyubimov ). 6 Chemical and Physical Characterizations of Potential New Chemical Entity ( Adegoke Adeniji and Adeboye Adejare ). 7 Permeability Assessment ( Srinivas Ganta, Puneet Sharma, and Sanjay Garg ). 8 How and Where Are Drugs Absorbed? ( Marival Bermejo and Isabel Gonzalez-Alvarez ). 9 Absorption of Drugs after Oral Administration ( Luis Granero and Ana Polache ). 10 Distribution: Movement of Drugs through the Body ( Jayanth Panyam and Yogesh Patil ). 11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution ( A. G. de Boer and P. J. Gaillard ). 12 Transporter Interactions in the ADME Pathway of Drugs ( Yan Zhang and Donald W. Miller ). 13 Accumulation of Drugs in Tissues ( Krishnamurthy Venkatesan, Deepa Bisht, and Mohammad Owais ). 14 Salt and Cocrystal Form Selection ( Ann W. Newman, Scott L. Childs, and Brett A. Cowans ). 15 Dissolution ( A.K. Tiwary, Bharti Sapra, and Subheet Jain ). 16 Stability: Physical and Chemical ( Eric M. Gorman, Brian E. Padden, and Eric J. Munson ). 17 Dosage Formulation ( Alexander V. Lyubimov ). 18 Cytochrome P450 Enzymes ( Eugene G. Hrycay and Stelvio M. Bandiera ). 19 Metabolism Kinetics ( Charles W. Locuson and Timothy S. Tracy ). 20 Drug Clearance ( Sree D. Panuganti and Craig K. Svensson ). 21 In Vitro Metabolism in Preclinical Drug Development ( Olavi Pelkonen, Ari Tolonen, Miia Turpeinen, and Jouko Uusitalo ). 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions ( Jane R. Kenny, Dermot F. McGinnity, Ken Grime, and Robert J. Riley ). 23 In Vivo Metabolism in Preclinical Drug Development ( Sevim Rollas ). 24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations ( Albert P. Li ). 25 Mechanisms and Consequences of Drug-Drug Interactions ( Dora Farkas, Richard I. Shader, Lisa L. von Moltke, and David J. Greenblatt ). 26 Species Comparison of Metabolism in Microsomes and Hepatocytes ( Niels Krebsfaenger ). 27 Metabolite Profi ling and Structural Identifi cation ( Mehran F. Moghaddam ). 28 Linkage between Toxicology of Drugs and Metabolism ( Ruiwen Zhang and Elizabeth R. Rayburn ). 29 Allometric Scaling ( William L. Hayton and Teh-Min Hu ). 30 Interrelationship between Pharmacokinetics and Metabolism ( James W. Paxton ). 31 Experimental Design Considerations in Pharmacokinetic Studies ( William W. Hope, Vidmantas Petraitis, and Thomas J. Walsh ). 32 Bioavailability and Bioequivalence Studies ( Alexander V. Lyubimov and Ihor Bekersky ). 33 Mass Balance Studies ( Jan H. Beumer, Julie L. Eiseman, and Merrill J. Egorin ). 34 Pharmacodynamics ( Beom Soo Shin, Dhaval Shah, and Joseph P. Balthasar ). 35 Physiologically Based Pharmacokinetic Modeling ( Harvey J. Clewell III, Micaela B. Reddy, Thierry Lave, and Melvin E. Andersen ). 36 Mathematical Modeling as a New Approach for Improving the Effi cacy/Toxicity Profi le of Drugs: The Thrombocytopenia Case Study ( Zvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheifetz, Irit Ziv, Meir Shoham, and Vladimir Vainstein ). 37 Regulatory Requirements for INDs/FIH (First in Human) Studies ( Shayne Cox Gad ). 38 Data Analysis ( Jayesh Vora and Pankaj B. Desai ). Index.
Other Titles: ADME and biopharmaceutical properties
Responsibility: [edited by] Shayne Cox Gad.
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"A valuable source of reference and one that I'm sure will get regular use. The diversity of topics should appeal to a variety of pharmaceutical scientists." ( The British Toxicology Newsletter , Read more...

 
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