skip to content
Predictive ADMET : integrative approaches in drug discovery and development Preview this item
ClosePreview this item
Checking...

Predictive ADMET : integrative approaches in drug discovery and development

Author: Jianling Wang; Laszlo Urban
Publisher: Hoboken, New Jersey : Wiley, [2014] ©2014
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs. Featuring case studies and lessons learned from real drug discovery and development, the text: helps users diagnose ADMET problems; presents appropriate recommendations; introduces the  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Additional Physical Format: Online version:
Predictive ADMET.
Hoboken, New Jersey : Wiley, [2014]
(DLC) 2013039200
Document Type: Book
All Authors / Contributors: Jianling Wang; Laszlo Urban
ISBN: 9781118299920 1118299922
OCLC Number: 858959012
Description: xiv, 596 pages : illustrations ; 25 cm
Contents: PREFACE ix CONTRIBUTORS xi I INTRODUCTION TO THE CURRENT SCIENTIFIC, CLINICAL, AND SOCIAL ENVIRONMENT OF DRUG DISCOVERY AND DEVELOPMENT 1 Current Social, Clinical, and Scientific Environment of Pharmaceutical R&D 3 Laszlo Urban, Jean-Pierre Valentin, Kenneth I Kaitin, and Jianling Wang 2 Polypharmacology and Adverse Bioactivity Profiles Predict Potential Toxicity and Drug-related ADRs 23 Teresa Kaserer, Veronika Temml, and Daniela Schuster II INTELLIGENT INTEGRATION AND EXTRAPOLATION OF ADMET DATA 3 ADMET Diagnosis Models 49 Bernard Faller, Suzanne Skolnik, and Jianling Wang 4 PATH (Probe ADME and Test Hypotheses): A Useful Approach Enabling Hypothesis-driven ADME Optimization 63 Leslie Bell, Suzanne Skolnik, and Dallas Bednarczyk 5 PK-MATRIX A Permeability: Intrinsic Clearance System for Prediction, Classification, and Profiling of Pharmacokinetics and Drug drug Interactions 89 Urban Fagerholm 6 Maximizing the Power of a Local Model for ADMET-property Prediction 103 Sebastien Ronseaux, Jeremy Beck, and Clayton Springer 7 Chemoinformatic and Chemogenomic Approach to ADMET 125 Virginie Y. Martiny, Ilza Pajeva, Michael Wiese, Andrew M. Davis, and Maria A. Miteva 8 Multiparameter Optimization of ADMET for Drug Design 145 Matthew D. Segall and Edmund J. Champness 9 PBPK: Integrating In Vitro and In Silico Data in Physiologically Based Models 167 Hannah M. Jones and Neil Parrott 10 Emerging Full Mechanistic Physiologically Based Modeling 189 Kiyohiko Sugano 11 Pharmacokinetic/Pharmacodynamic Modeling in Drug Discovery: A Translational Tool to Optimize Discovery Compounds Toward the Ideal Target-specific Profile 211 Patricia Schroeder III ASSESSMENT AND MITIGATION OF CRITICAL CLINICALLY RELEVANT ADMET RISKS IN DRUG DISCOVERY AND DEVELOPMENT 12 In Vitro In Silico Tools to Predict Pharmacokinetics of Poorly Soluble Drug Compounds 235 Christian Wagner and Jennifer B. Dressman 13 Evaluation of the Collective Impact of Passive Permeability and Active Transport on In Vivo Blood-brain Barrier and Gastrointestinal Drug Absorption 263 Donna A. Volpe, Hong Shen, and Praveen V. Balimane 14 Integrated Assessment of Drug Clearance and Cross-Species Scalability 291 Kevin Beaumont, James R. Gosset, and Chris E. Keefer 15 Practical Anticipation of Human Efficacious Doses and Pharmacokinetics using Preclinical In Vitro and In Vivo Data 319 Tycho Heimbach, Rakesh Gollen, and Handan He 16 Management and Mitigation of Human Drug drug Interaction Risks in the Drug Discovery and Development Phases 353 Heidi J. Einolf and Imad Hanna 17 Integrated Assessment and Clinical Translation of In Vitro Off-target Safety Pharmacology Risks 397 Patrick Y. Muller and Christian F. Trendelenburg 18 Integrated Risk Assessment of Cardiovascular Safety in Drug Discovery 407 Gul Erdemli and Ruth L. Martin 19 Drug-induced Hepatotoxicity: Advances in Preclinical Predictive Strategies and Tools 433 Donna M. Dambach 20 Carcinogenicity and Teratogenicity Assessment 467 Hans-Jorg Martus, David Beckman, and Lutz Mueller 21 Nephrotoxicity: Development of Biomarkers for Preclinical and Clinical Application 491 Frank Dieterle and Estelle Marrer IV SUCCESS STORIES AND LESSONS LEARNED 22 Early Intervention with Formulation Strategies for Multidimensional Problems to Optimize for Success 507 Stephanie Dodd, Christina Capacci-Daniel, Christopher Towler, Riccardo Panicucci, and Keith Hoffmaster 23 Cytochrome P450-mediated Drug Interaction and Cardiovascular Safety: The Seldane to Allegra Transformation 523 F. Peter Guengerich 24 Clinical Toxicity Profile of VEGF Inhibitors 535 Mark P. S. Sie and Ferry A. L. M. Eskens 25 Cardiomyopathy: Drug Induced and Predisposed 555 Shirley A. Aguirre and Eileen R. Blasi 26 Safety Management by Pharmacokinetic Considerations: Ranibizumab (Lucentis) and Bevacizumab (Avastin) 569 Nicole H. Siegel and Manju L. Subramanian INDEX 583
Responsibility: edited by Jianling Wang, Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Cambridge, MA, USA, Laszlo Urban, Preclinical Safety Profiling, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

Abstract:

By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and  Read more...

Reviews

Editorial reviews

Publisher Synopsis

In conclusion, this volume fulfills its promise of being a very useful tool for guidance and diagnosis on ADMET matters, and I would recommend it to any scientist in the field. (ChemMedChem, 1 June Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/858959012> # Predictive ADMET : integrative approaches in drug discovery and development
    a schema:CreativeWork, schema:Book ;
   library:oclcnum "858959012" ;
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nju> ;
   schema:about <http://dewey.info/class/615.19/e23/> ;
   schema:about <http://experiment.worldcat.org/entity/work/data/1401079517#Topic/medicaments_mise_au_point> ; # Médicaments--Mise au point
   schema:about <http://id.worldcat.org/fast/898670> ; # Drug development
   schema:about <http://experiment.worldcat.org/entity/work/data/1401079517#Topic/drug_discovery_methods> ; # Drug Discovery--methods
   schema:about <http://experiment.worldcat.org/entity/work/data/1401079517#Topic/pharmacokinetics> ; # Pharmacokinetics
   schema:bookFormat bgn:PrintBook ;
   schema:copyrightYear "2014" ;
   schema:datePublished "2014" ;
   schema:description ""By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs. Featuring case studies and lessons learned from real drug discovery and development, the text: helps users diagnose ADMET problems; presents appropriate recommendations; introduces the current clinical practice for drug discovery and development; and consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data"--"@en ;
   schema:editor <http://viaf.org/viaf/294303501> ; # Laszlo Urban
   schema:editor <http://viaf.org/viaf/307422370> ; # Jianling Wang
   schema:exampleOfWork <http://worldcat.org/entity/work/id/1401079517> ;
   schema:inLanguage "en" ;
   schema:isSimilarTo <http://worldcat.org/entity/work/data/1401079517#CreativeWork/predictive_admet> ;
   schema:name "Predictive ADMET : integrative approaches in drug discovery and development"@en ;
   schema:productID "858959012" ;
   schema:workExample <http://worldcat.org/isbn/9781118299920> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/858959012> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/1401079517#Topic/drug_discovery_methods> # Drug Discovery--methods
    a schema:Intangible ;
   schema:name "Drug Discovery--methods"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1401079517#Topic/medicaments_mise_au_point> # Médicaments--Mise au point
    a schema:Intangible ;
   schema:name "Médicaments--Mise au point"@en ;
    .

<http://id.worldcat.org/fast/898670> # Drug development
    a schema:Intangible ;
   schema:name "Drug development"@en ;
    .

<http://viaf.org/viaf/294303501> # Laszlo Urban
    a schema:Person ;
   schema:birthDate "1951" ;
   schema:familyName "Urban" ;
   schema:givenName "Laszlo" ;
   schema:name "Laszlo Urban" ;
    .

<http://viaf.org/viaf/307422370> # Jianling Wang
    a schema:Person ;
   schema:birthDate "1958" ;
   schema:familyName "Wang" ;
   schema:givenName "Jianling" ;
   schema:name "Jianling Wang" ;
    .

<http://worldcat.org/entity/work/data/1401079517#CreativeWork/predictive_admet>
    a schema:CreativeWork ;
   rdfs:label "Predictive ADMET." ;
   schema:description "Online version:" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/858959012> ; # Predictive ADMET : integrative approaches in drug discovery and development
    .

<http://worldcat.org/isbn/9781118299920>
    a schema:ProductModel ;
   schema:isbn "1118299922" ;
   schema:isbn "9781118299920" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.