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Primary Biliary Cirrhosis : From Pathogenesis to Clinical Treatment

Author: Keith D Lindor; E Jenny Heathcote; Raoul Poupon
Publisher: Dordrecht : Springer Netherlands, 1998.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume, the proceedings of a one-day symposium held in Chicago, USA, on November 6, 1997, provides an update for hepatologists, gastroenterologists, and basic scientists with an interest in primary biliary cirrhosis. New insights into the pathogenesis and the natural history of the disease are discussed, and approaches to management of the complications as well as newer therapeutic options are presented by  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Keith D Lindor; E Jenny Heathcote; Raoul Poupon
ISBN: 9789401148849 9401148848
OCLC Number: 851384591
Description: 1 online resource (xv, 176 pages)
Contents: Section I: Natural History and Pathogenesis --
1 Natural history and demography of primary biliary cirrhosis --
2 Immune basis for PBC --
3 Isolation and cloning of antimitochondrial antibodies --
4 Significance of antimitochondrial antibody profiles in primary biliary cirrhosis --
5 Chloride/bicarbonate exchange in PBC: a clue for pathogenesis? --
6 Molecular considerations of primary biliary cirrhosis --
7 Animal models of primary biliary cirrhosis --
8 Fibrogenesis in PBC --
9 Natural history models of primary biliary cirrhosis --
Section II: Management of Primary Biliary Cirrhosis --
10 Portal hypertension in patients with primary biliary cirrhosis --
11 Management of primary biliary cirrhosis: osteoporosis --
12 Fatigue in the primary biliary cirrhosis patient --
13 The pruritus of cholestasis: behavioral studies shed light on its pathogenesis --
14 Old and new immunosuppressant drugs: mechanisms and potential value --
15 Methotrexate and colchicine in the treatment of primary biliary cirrhosis --
16 Corticosteroids in PBC --
17 Ursodeoxycholic acid treatment of primary biliary cirrhosis: potential mechanisms of action --
18 Ursodiol and combination therapy --
19 Primary biliary cirrhosis transplantation and recurrent disease --
20 New clinical trials in primary biliary cirrhosis: design and endpoints.
Responsibility: edited by Keith D. Lindor, E. Jenny Heathcote, Raoul Poupon.

Abstract:

The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase  Read more...

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