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Primer on the metabolic bone diseases and disorders of mineral metabolism

Author: Clifford J Rosen; R Bouillon; Juliet Compston; Vicki Rosen
Publisher: Ames, Iowa : Wiley-Blackwell, 2013.
Edition/Format:   eBook : Document : English : 8th edView all editions and formats
Summary:
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Primer on the metabolic bone diseases and disorders of mineral metabolism.
Ames, Iowa : Wiley-Blackwell, 2013
(DLC) 2013002831
(OCoLC)826287961
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Clifford J Rosen; R Bouillon; Juliet Compston; Vicki Rosen
ISBN: 9781118453902 1118453905 9781118453926 1118453921 1118453883 9781118453889 9781118453896 1118453891 9781118453919 1118453913
OCLC Number: 851315970
Description: 1 online resource (xxvi, 1078 pages)
Contents: Cover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References. 2: Signal Transduction Cascades Controlling Osteoblast Differentiation; Introduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-ß Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References. 4: Osteocytes; Introduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold. Abbreviations; References; 6: The Composition of Bone; Introduction; The Composite; The mineral; Collagen; Noncollagenous Proteins; Serum-derived proteins; Proteoglycans; Glycosylated proteins; Small integrin-binding ligand, N-glycosylated protein, and other glycoproteins with cell attachment activity; Gla-containing proteins; Other Components; References; 7: Assessment of Bone Mass and Microarchitecture in Rodents; Introduction; Radiographs; Peripheral Dual-Energy X-Ray Absorptiometry; Peripheral Quantitative Computed Tomography; Magnetic Resonance Imaging; Microcomputed Tomography. Nanocomputed Tomography; Imaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage; Osteoblasts.
Responsibility: editor-in-chief, Clifford J. Rosen ; senior associate editors, Roger Bouillon, Juliet E. Compston, Vicki Rosen ; associate editors, Douglas P. Bauer [and others].
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Abstract:

Now in an updated eighth edition, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism comprehensively covers key diseases of the bone and disorders of mineral metabolism.  Read more...

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