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Principles of clinical pharmacology

Author: Arthur J Atkinson, Jr.
Publisher: San Diego, CA : Academic Press, 2001.
Edition/Format:   Print book : EnglishView all editions and formats

Focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. This book includes coverage ranging from drug discovery and development to  Read more...


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Additional Physical Format: Online version:
Principles of clinical pharmacology.
San Diego, CA : Academic Press, 2001
Online version:
Principles of clinical pharmacology.
San Diego, CA : Academic Press, 2001
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Arthur J Atkinson, Jr.
ISBN: 0120660601 9780120660605
OCLC Number: 48083877
Description: xvi, 460 pages : illustrations ; 29 cm
Contents: IntroductionPART 1: PHARMACOKINETICS:Clinical pharmacokinetics.Compartmental analysis of drug distribution.Drug absorption and bioavailability.Effects of renal disease on pharmacokinetics.Kinetics of hemodialysis and hemofiltration.Effects of liver disease on pharmacokinetics.Noncompartmental vs. compartmental approaches to pharmacokinetic analysis.Distributed models of drug kinetics.Population pharmacokinetics. PART 2: DRUG METABOLISM AND TRANSPORT:Pathways of drug metabolism.Chemical assay of drugs and drug metabolites.Pharmacogenetics.Drug interactions.Biochemical mechanisms of drug toxicity.Equilibrative and concentrative transport. PART 3: ASSESSMENT OF DRUG EFFECTS:Physiological and laboratory markers of drug effect.Dose response and concentration response analysis.Kinetics of pharmacologic effect.Disease progression models.PART 4: OPTIMIZING AND EVALUATING DRUG THERAPY:Sex differences in pharmacokinetics and pharmacodynamics.Drug therapy in pregnant and nursing women.Drug therapy in neonates and pediatric patients.Drug therapy in the elderly.Clinical analysis of adverse drug reactions.Quality assessment of drug therapy.PART 5: DRUG DISCOVERY AND DEVELOPMENT:Project management.Drug discovery.Pre-clinical development.Animal scale up.Phase I studies.PK and PD considerations in the development of biotechnology products and large molecules. Design of clinical development programs.Role of the FDA in guiding drug development.Appendix I: Table of Laplace TransformsAppendix II: Answers to Study Problems
Responsibility: [edited by] Arthur J. Atkinson, Jr. [and others].
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"...this book fulfills the long-felt need for an updated publication in Clinical Pharmacology."-INDIAN JOURNAL OF PHARMACOLOGY (2003)"...this book is for the reader who wants a detailed in- depth Read more...

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