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Principles of molecular oncology

Author: Miguel H Bronchud
Publisher: Totowa, N.J. : Humana Press, ©2004.
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Summary:
Drawing on four years of significant scientific advances and clinical developments, the editors of Principles of Molecular Oncology, Second Edition, have thoroughly updated the highly praised first edition and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Principles of molecular oncology.
Totowa, N.J. : Humana Press, ©2004
(DLC) 2003049986
(OCoLC)52086182
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Miguel H Bronchud
ISBN: 1592596649 9781592596645
OCLC Number: 54760294
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xxi, 709) : illustrations
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Part 1. Molecular markers. Chapter 1. Selecting the right targets for cancer therapy / Miguel H. Bronchud --
Chapter 2. Clinical importance of prognostic factors: moving from scientifically interesting to clinically useful / Daniel F. Hayes --
Chapter 3. Genetic markers in sporadic tumors / Antonella Aiello [and others] --
Chapter 4. Genetic markers in breast tumors with hereditary predisposition / Tatyana A. Grushko and Olufunmilayo I. Olopade --
Chapter 5. Cellular and tissue markers in solid tumors / Barbro Linderholm [and others] --
Chapter 6. Molecular and pathologic characterization of human tumors / Chris Jones, Ming-Qing Du, and Sunil R. Lakhani --
Chapter 7. Circulating tumor markers / Alan Horwich and Gill Ross --
Chapter 8. Proteomics-based approaches: new opportunities in cancer research / Rachel A. Craven, Peter J. Selby, and Rosamonde E. Banks --
Part 2. Diseased regulatory pathways. Chapter 9. Growth factor signaling pathways in cancer / Daniel Kalderon --
Chapter 10. Estrogen action and breast cancer / Jennifer E. Fox, Hong Liu, and V. Craig Jordan --
Chapter 11. Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics / Miguel H. Bronchud [and others] --
Chapter 12. Angiogenesis switch pathways / Jaume Piulats and Francesc Mitjans --
Chapter 13. Invasion and metastasis / Maria Rosa Bani and Raffaella Giavazzi --
Chapter 14. Molecular pathways of drug resistance / Linda E. Broker, Jose A. Rodriguez, and Giuseppe Giaccone --
Chapter 15. Genomic instability, DNA repair pathways, and cancer / Gabriel Capella and Miguel Angel Peinado --
Part 3. Future directions. Chapter 16. Immunotherapy for human cancer: evidence and obstacles / Angelo A. Cardoso [and others] --
Chapter 17. Treatment with monoclonal antibodies / Gisela Schwab, Lorin Roskos, and C. Geoffrey Davis --
Chapter 18. Emerging molecular therapies: drugs interfering with signal transduction pathways / Richard Baird and Paul Workman --
Chapter 19. Treatment of carcinogenesis / M. Suzanne Stratton [and others] --
Chapter 20. Suicide gene therapy / Ion Niculescu-Duvaz and Caroline J. Springer.
Responsibility: edited by Miguel H. Bronchud [and others] ; forewords by E. Donnall Thomas, David J. Weatherall, Derek Crowther.

Abstract:

Drawing on four years of significant scientific advances and clinical developments, the editors of Principles of Molecular Oncology, Second Edition, have thoroughly updated the highly praised first edition and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small-molecular-weight compounds. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition reaffirms this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins-with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, Principles of Molecular Oncology, Second Edition not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much-neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce cancer cell proliferation and significantly reduce metastasis.

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