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Principles of Peptide Synthesis

Author: Miklos Bodanszky
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1984.
Series: Reactivity and structure, 16.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Miklos Bodanszky
ISBN: 9783642967634 3642967639
OCLC Number: 851371122
Description: 1 online resource (xvi, 308 pages).
Contents: I. Introduction --
References of Chapter 1 --
II. Activation and Coupling --
A. Activation --
B. Coupling --
C. Coupling Methods --
References of Chapter II --
III. Reversible Blocking of Amino and Carboxyl Groups --
A. General Aspects --
B. Protection of the Carboxyl Group --
C. Protection of the Amino Group --
References of Chapter III --
IV. Semipermanent Protection of Side Chain Functions --
A. Carboxyl Groups of Aspartyl and Glutamyl Residues --
B. Side Chain Amino Groups of Lysine and Ornithine --
C. Hydroxyl Groups in Serine, Threonine and Tyrosine --
D. The Sulfhydryl Group in Cysteine --
E. The Guanidino Group of Arginine --
F. Imidazole in Histidine --
G. The Thioether in Methionine --
H. The Indole Nitrogen in Tryptophan --
I. The Carboxamide Groups in Asparagine and Glutamine --
References of Chapter IV --
V. Side Reactions in Peptide Synthesis --
A. Side Reactions Initiated by Proton Abstraction --
B. Side Reactions Initiated by Protonation --
C. Side Reactions Due to Overactivation --
D. Side Reactions Related to Individual Amino Acid Residues --
References of Chapter V --
VI. Tactics and Strategy in Peptide Synthesis --
A. Tactics --
B. Strategies --
C. Disulfide Bridges --
D. Synthesis of Cyclic Peptides --
E. Sequential Polypeptides --
F. Partial Synthesis (Semisynthesis) --
References of Chapter VI --
VII. Techniques for the Facilitation of Peptide Synthesis --
A. Solid Phase Peptide Synthesis (SPPS) --
B. Synthesis in Solution --
References of Chapter VII --
VIII. Recent Developments and Perspectives --
A. Formation of the Peptide Bond --
B. Protection --
C. Side Reactions --
D. Solid Phase Peptide Synthesis --
E. Catalysis. --
References of Chapter VIII --
Author Index.
Series Title: Reactivity and structure, 16.
Responsibility: by Miklos Bodanszky.

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