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Principles of translational science in medicine : from bench to bedside

Author: Martin Wehling
Publisher: London : Academic Press, [2015]
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Summary:
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Martin Wehling
ISBN: 9780128007211 0128007214
OCLC Number: 906575076
Description: 1 online resource.
Contents: Front Cover; Principles of Translational Science in Medicine; Copyright; Contents; List of Contributors; Preface; Chapter 1 --
Introduction and Definitions; WHAT IS TRANSLATIONAL MEDICINE?; PRIMARY TRANSLATION VERSUS SECONDARY TRANSLATION; THE HISTORY OF TRANSLATIONAL MEDICINE, OBSTACLES, AND REMITS; WHAT TRANSLATIONAL MEDICINE CAN AND CANNOT DO; THE PRESENT STATUS OF TRANSLATIONAL MEDICINE (INITIATIVES AND DEFICIENCIES); TRANSLATIONAL SCIENCE IN MEDICINE: THE CURRENT CHALLENGE; REFERENCES; Chapter 2 --
Target Identification and Validation Chapter 2.1.1 --
"Omics" Translation: A Challenge for Laboratory MedicineINTRODUCTION; "OMICS": WHAT DOES IT MEAN?; PROTEOMICS AS A PARADIGM OF PROBLEMS IN TRANSLATIONAL MEDICINE; DEVELOPMENT OF BIOMARKERS: FROM DISCOVERY TO CLINICAL APPLICATION; DISCOVERY; IDENTIFICATION/CHARACTERIZATION; VALIDATION; STANDARDIZATION/HARMONIZATION; CLINICAL ASSOCIATION AND CLINICAL BENEFIT; TRANSLATING OMICS INTO CLINICAL PRACTICE; CONTINUUM OF TRANSLATION RESEARCH AND OMICS; CONCLUSIONS; REFERENCES; Chapter 2.1.2 --
"Omics" Technologies: Promises and Benefits for Molecular Medicine; INTRODUCTION; GENOMICS METABOLOMICSCONCLUSION; REFERENCES; Chapter 2.1.3 --
Potency Analysis of Cellular Therapies: The Role of Molecular Assays; POTENCY TESTING; COMPLEXITIES ASSOCIATED WITH POTENCY TESTING OF CELLULAR THERAPIES; FACTORS AFFECTING THE POTENCY OF CELLULAR THERAPIES; MEASURING POTENCY OF CELLULAR THERAPIES; GENE EXPRESSION ARRAYS FOR POTENCY TESTING; POTENTIAL APPLICATIONS OF GENE EXPRESSION PROFILING FOR POTENCY TESTING; MICRORNAS AS POTENCY ASSAYS; CONCLUSIONS; REFERENCES; Chapter 2.1.4 --
Translational Pharmacogenetics to Support Pharmacogenetically Driven Clinical Decision Making; INTRODUCTION PHARMACOGENETICS AS A TOOL FOR IMPROVING INDIVIDUAL DRUG THERAPYTYPES OF DRUG THERAPIES THAT MIGHT PROFIT FROM PHARMACOGENETIC DIAGNOSTICS; THE STATUS OF TRANSLATIONAL PHARMACOGENETICS IN VARIOUS DRUG THERAPY FIELDS; TRANSLATIONAL PHARMACOGENETICS AND THE NEED FOR CLINICAL STUDIES TO SUPPORT PHARMACOGENETICALLY DRIVEN PRESCRIBING; REFERENCES; Chapter 2.1.5 --
Tissue Biobanks; INTRODUCTION; PRINCIPLES AND TYPES OF TISSUE BIOBANKS: PROS AND CONS; DEVELOPMENTS IN VASCULAR BIOBANKING RESEARCH AND CLINICAL RELEVANCE; CHALLENGES FOR FUTURE BIOBANKS; SUMMARY; REFERENCES Chapter 2.1.6 --
Animal Models: Value and Translational PotencyWHAT IS THE VALUE OF ANIMAL MODELS? PATHOPHYSIOLOGICAL CONCEPTS; WHAT IS A GOOD ANIMAL MODEL FOR TRANSLATIONAL RESEARCH?; WHAT IS THE TRANSLATIONAL VALUE OF ANIMAL MODELS?; REMEDIES FOR FAILED TRANSLATION: IMPROVING PRECLINICAL RESEARCH; SUMMARY; REFERENCES; Chapter 2.1.7 --
Localization Technologies and Immunoassays: Promises and Benefits for Molecular Medicine; INTRODUCTION; LOCALIZATION TECHNOLOGIES; IMMUNOASSAYS; CASE STUDY: SCREENING OF A BIOMARKER FOR KIDNEY INJURY USING LOCALIZATION AND IMMUNOASSAYS; REFERENCES Chapter 2.1.8 --
Biomarkers in the Context of Health Authorities and Consortia
Responsibility: edited by Martin Wehling, Department of Clinical Pharmacology Mannheim, University of Heidelberg, Mannheim, Germany.

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Previous edition: Cambridge: Cambridge University Press, 2010.  Read more...

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