It's a case of malaria versus murder when private dick extraordinare Kinky Friedman comes down with a tropical disease, in the jungle known as New York City, and is confined to his loft on Vandam Street in lower Manhattan, a prisoner in his own home with only his cat and black puppet head as company (neither of whom are great conversationalists). With little to do but stare out the window in between bedridden bouts of fever and hallucinations, Kinky calls on assistance from the stalwart Village Irregulars, who proceed to dish out their own uniquely skewed brand of tea and sympathy, turning the loft into a virtual Mardi Gras of confusion and drunken debauchery. Suffering almost as much from company overload as from his fever, Kinky welcomes a rare moment of calm as he finds himself once again alone in his loft. Resuming his position at the kitchen window, he spots a pretty young woman in an apartment across the street. What he hopes might be titillating turns terrifying, however, as a man joins the woman and proceeds to attack her. Sure that he's witnessed a crime, Kinky calls in the cops, but, upon investigating his claim, they can find neither a victim nor an apartment across the street. In addition, no one else saw or heard anything that would indicate a crime had taken place. Was it foul play or merely a fevered dream? Convinced that their friend is about to slip off into the land of eternal slumber, the Village Irregulars increase their vigilance and in the process raise the Kinkster's irritability level to an all-time high. Not to be deterred, however, Kinky sticks to his story and is rewarded when a few days later he sees the man in the apartment again, but this time with a gun.