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The problem of excitability; electrical excitability and ionic permeability of the nerve membrane

Author: Boris Izrailevich Khodorov
Publisher: New York, Plenum Press [1974]
Edition/Format:   Print book : EnglishView all editions and formats

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Additional Physical Format: Online version:
Khodorov, Boris Izrailevich.
Problem of excitability.
New York, Plenum Press [1974]
Document Type: Book
All Authors / Contributors: Boris Izrailevich Khodorov
ISBN: 0306305933 9780306305931
OCLC Number: 827723
Notes: Translation of Problema vozbudimosti.
Description: xvii, 329 pages illustrations 24 cm
Contents: I. Excitability and Relationships Between the Initial and Critical Values of the Membrane Potential.- Changes in Vt associated with primary shifts of Er.- Physiological electrotonus.- Effect of afferent stimulation.- Wedensky's "pessimal" inhibition.- Relative refractoriness.- Effects of potassium ions.- Changes in Vt resulting from a primary shift of Ec.- Effects of calcium ions.- Effects of local and general anesthetics.- II. The Resting Potential.- III. Passive and Subthreshold Active Changes in the Membrane Potential.- Passive changes of membrane potential.- The local response.- Historical.- Method of detecting the local response.- Properties of the local response.- Role of the local response in critical membrane depolarization.- IV. The Action Potential.- Historical.- Effect of changes in external and internal sodium and potassium ion concentrations on action potential generation.- Movement of ions through the membrane during activity.- Investigation by the use of labeled atoms.- Investigation of ionic currents by the voltageclamp method.- Evidence for subdivision of the ionic currents.- The sodium current.- The potassium current.- Changes in ionic permeability.- Quantitative description of ionic currents.- A mathematical model of the membrane of the squid giant axon.- Medullated nerve fibers.- The use of the mathematical model to analyze the kinetics of ionic currents in different phases of development of the action potential.- V. Dependence of Action Potential Parameters on the Constants of Membrane Ionic Permeability.- Maximal sodium permeability $$\rm \overline P _{Na} $$Na.- Steady-state sodium inactivation (1 - h?) and time constant Th.- Reactivity of the sodium system (sensitivity of PNa to changes in membrane potential).- The threshold potential.- Maximal steepness of rise of the ascending phase of the action potential.- Amplitude of the action potential.- Duration of the action potential.- Time constant of sodium activation Tm.- Maximal potassium permeability $$\rm \overline P _K $$.- Reactivity of the potassium system (sensitivity of $$\rm \overline P _K $$ to changes in membrane potential).- Effects of an increase in reactivity of thepotassium system.- Effects of a decrease in reactivity of the potassium activating system.- Time constant of potassium activation (Tn).- Assessment of the character of changes in ionic permeability of the membrane from changes in the action potential.- VI. Analysis of Threshold Conditions of Stimulation and the Relationship Between the Threshold Current and Threshold Potential.- The strength versus duration curve.- Character of critical depolarization of the membrane during the action of pulses of current of different duration. Nature of the utilization time.- Relationship between the threshold current and the passive and active properties of the membrane.- The rheobase.- The rheobase and passive properties of the membrane.- Relationship between rheobase and constants of ionic permeability of the membrane.- Threshold current for stimuli of short duration. Dependence on passive properties of the membrane.- Capacitance of the membrane (Cm).- Resistance of the membrane (Rm).- Threshold current for short stimuli as a function of the active properties of the membrane.- Time constant of sodium activation.- Maximal sodium and potassium permeabilities.- VII. Role of the Rate of Change of the Stimulus. The Phenomenon of Accommodation.- The accommodation curve.- The mechanism of accommodation.- Minimal gradient as a function of the constants of ionic permeability of the membrane.- Accommodation and repetitive responses.- VIII. Cable Properties and Geometry of Excitable Structures and Parameters of Their Electrical Activity.- The propagated action potential.- Threshold conditions of stimulation.- The threshold potential.- The threshold current.- The strength versus duration curve.- Repetitive responses in a continuous axon.- Effects of stimulation of excitable structures with a functionally nonuniform membrane.- The relationship between the velocity of conductance of the action potential and the cable properties and excitability of the fiber.- Conduction of impulses along a nonuniform fiber.- Some properties of spike conduction from a medullated into a nonmedullated segment of a nerve fiber.- Compensatory changes in ionic currents during conduction of the impulse along a nonuniform fiber.- IX. Molecular Mechanisms of Ionic Permeability of the Excitable Membrane.- Functional architecture of the excitable membrane.- Enzymes.- Cations.- Anions.- Dilution of electrolytes in the internal medium.- Poisons.- The hypothesis of ionic carriers.- The hypothesis of ion pores.- Specificity of the ion channels.- The possible role of Ca++ ions in the mechanism of opening and closing of the ionic channels.- Hypotheses on conformational changes in the membrane.- Investigations of mechanisms of the changes in ionic permeability on artificial membranes.- Precipitation membranes.- Phospholipid membranes.- Conclusion.- Addendum.
Other Titles: Problema vozbudimosti.
Responsibility: [by] B.I. Khodorov. Translated from Russian by Basil Haigh. Translation editor: F.A. Dodge, Jr.


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