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Progenitor and stem cell technologies and therapies

Author: Anthony Atala
Publisher: Cambridge, UK ; Philadelphia, PA : Woodhead Pub., 2012.
Series: Woodhead Publishing in materials.
Edition/Format:   Print book : EnglishView all editions and formats

Part one provides an introduction to this important field whilst part two discusses basic principles of stem cells. Part three reviews methods for enabling stem cell therapies whilst the final part  Read more...


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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Anthony Atala
ISBN: 9781845699840 184569984X 9780857096074 0857096079
OCLC Number: 755698576
Description: xxiii, 536 pages : illustrations ; 24 cm.
Contents: Dedication Contributor contact details Introduction Part I: Basic principles of stem cells Chapter 1: Basic principles for stem cell culture Abstract: 1.1 Introduction 1.2 Understanding and standardization of in vitro culture systems 1.3 Quality assurance 1.4 Documentation 1.5 Safety 1.6 Legal, ethical and regulatory compliance 1.7 Education and training 1.8 Conclusion 1.9 Acknowledgement Chapter 2: Basic principles of human embryonic stem cells Abstract: 2.1 Introduction: biological properties of human embryonic stem cells (hESC) 2.2 Historical overview 2.3 Human embryonic stem cells (hESC) in therapy - current status and strategies for the future 2.4 Human embryonic stem cells (hESC) in drug discovery - current status and strategies for the future 2.5 Specific mutation-carrying (SMC) human embryonic stem cells (hESC) 2.6 Human embryonic stem cells (hESC) utilization, the next step 2.7 Conclusion Chapter 3: Basic principles in generating induced pluripotent stem cells Abstract: 3.1 Introduction 3.2 Evolution of reprogramming and the birth of induced pluripotency 3.3 Current methods for induced reprogramming 3.4 Conclusions and future prospects Chapter 4: Basic principles of amniotic fluid and placenta stem cells Abstract: 4.1 Introduction 4.2 Amniotic fluid and placenta in developmental biology 4.3 Isolation and characterization of progenitor cells 4.4 Differentiation of amniotic fluid- and placenta-derived progenitor cells 4.5 In vivo behavior of amniotic fluid stem cells 4.6 Amniotic fluid and placenta for cell therapy 4.7 Conclusion 4.8 Acknowledgment Chapter 5: Basic principles of cord blood stem cells Abstract: 5.1 Introduction: history of cord blood stem cell technology 5.2 Cord blood collection, processing and storage 5.3 Public and private cord blood banking 5.4 Cord blood haemopoietic stem cell transplantation 5.5 Cord blood mesenchymal stem cells 5.6 Current research and future developments 5.7 Cord blood transfusion 5.8 Conclusion Chapter 6: Basic principles of multipotent stem cells Abstract: 6.1 Introduction 6.2 Hematopoietic stem cells (HSC) 6.3 Mesenchymal stem cells (MSC) 6.4 Adult stem cells with broader potential 6.5 In vitro and in vivo differentiation potential of multipotent adult progenitor cells (MAPC) 6.6 Immunomodulatory properties of multipotent adult progenitor cells (MAPC) 6.7 Conclusion Part II: Enabling cell therapy Chapter 7: Intellectual property claims to stem cell technologies: research, clinical testing and product sales Abstract: 7.1 Introduction 7.2 International overview of patent laws and stem cell policies 7.3 Introduction to the international stem cell patent landscape 7.4 Human embryonic stem cell patents 7.5 Advances in induced pluripotent stem cell patents (iPS cells) 7.6 Models for access to, and management of, stem cell patents 7.7 Conclusion 7.8 Acknowledgments Chapter 8: Regulatory considerations of stem and progenitor cell-based products: US Food and Drug Administration Abstract: 8.1 Introduction 8.2 Preparing the cellular component: chemistry, manufacturing and control considerations 8.3 Preclinical testing: pharmacology/toxicology considerations 8.4 Clinical trial considerations 8.5 Combination products: considerations when combining stem/progenitor cells with other components 8.6 Conclusion and future regulatory tools development 8.7 Acknowledgments Chapter 9: Cell therapy commercialisation Abstract: 9.1 Introduction: cells as therapies 9.2 The field to date 9.3 Commercialisation 9.4 Manufacturing 9.5 Future trends 9.6 Conclusion 9.7 Acknowledgements 9.8 Sources of further information Chapter 10: Stem cell tourism Abstract: 10.1 Introduction 10.2 Scope of the phenomenon 10.3 Problems relating to stem cell tourism 10.4 Responses 10.5 Conclusion 10.6 Acknowledgments Part III: Tissue-specific progenitor cells Chapter 11: Adipose tissue-derived stem cell biology and therapy Abstract: 11.1 Introduction 11.2 Characterization of adipose tissue-derived stromal cells 11.3 Advantages of adipose tissue-derived stem cells over other cell sources 11.4 Adipose tissue-derived stromal cells for cardiovascular repair: a joint clinical and experimental approach 11.5 Conclusion: perspectives and open questions 11.6 Acknowledgements Chapter 12: Umbilical cord blood (UCB) progenitor and stem cell biology and therapy Abstract: 12.1 Introduction 12.2 Biological characterization of umbilical cord blood (UCB) stem/progenitor cells 12.3 Therapeutic potential of umbilical cord blood (UCB) stem/progenitor cells for tissue repair or regeneration 12.4 Conclusion and future perspectives Chapter 13: Auditory progenitor stem cell biology and therapy Abstract: 13.1 Introduction 13.2 Sources of auditory progenitors 13.3 Transdifferentiation or developmental progression? 13.4 Which is the best cell type and stage for transplantation? 13.5 Future trends Chapter 14: Olfactory mucosa: neural stem and progenitor cells for nervous system repair and cell models of brain disease Abstract: 14.1 Introduction 14.2 Olfactory mucosa as source of tissue-resident stem cells 14.3 Cells with clinical application 14.4 Preclinical and clinical studies 14.5 Olfactory stem cell models of human disease 14.6 Conclusion 14.7 Acknowledgements Chapter 15: Oral cavity progenitor and stem cell biology and therapy Abstract: 15.1 Introduction 15.2 Embryonic development of teeth and supporting tissues 15.3 Tooth bud-derived stem cell types and differentiation potential 15.4 Stem cells present in postnatal teeth 15.5 Unsolved problems in the use of dental stem cells 15.6 Conclusion Chapter 16: Bone marrow mesenchymal progenitor and stem cell biology and therapy Abstract: 16.1 Introduction 16.2 Mesenchymal stem cell (MSC) biology 16.3 Mesenchymal stem cell (MSC) therapy 16.4 Conclusion Chapter 17: Progenitor and stem cell therapies for cartilage repair Abstract: 17.1 Introduction 17.2 Cell-based therapies for cartilage repair 17.3 Tissue engineering strategies for cartilage repair 17.4 Hurdles for cartilage tissue regeneration 17.5 Conclusion and future trends 17.6 Acknowledgement Chapter 18: Cardiac stem and progenitor cell biology and therapy Abstract: 18.1 Introduction: current concept of cardiac tissue homeostasis 18.2 From none to plenty: cardiac stem/progenitor cell populations within adult myocardium 18.3 Origin of cardiac stem cells in the adult human heart 18.4 Cardiac stem cell niche 18.5 Regeneration boosting 18.6 Conclusions Chapter 19: Renal progenitor and stem cell biology and therapy Abstract: 19.1 Introduction 19.2 Endogenous renal progenitor cells and regeneration 19.3 Summary and conclusions Chapter 20: Lung progenitor and stem cell biology and therapy Abstract: 20.1 Introduction: definitions of a diverse population 20.2 Lung development and stem cell zones 20.3 Resident lung stem cells and their niches 20.4 Circulating bone marrow-derived stem cells which home to the lung 20.5 Techniques for identification of lung stem cells 20.6 Disorders of lung stem cells and clinical applications in lung diseases 20.7 Induced pluripotent stem cells (iPSCs) 20.8 Conclusion: future directions for lung stem cells through bioengineered lung tissue 20.9 Acknowledgments Chapter 21: Genitourinary progenitor and stem cell biology and therapy Abstract: 21.1 Introduction 21.2 The basics of tissue engineering 21.3 Cells for use in urological tissue engineering 21.4 Biomaterials for urological tissue engineering 21.5 Tissue engineering of specific urologic structures 21.6 Conclusion 21.7 Acknowledgments Index
Series Title: Woodhead Publishing in materials.
Responsibility: edited by Anthony Atala.
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I would recommend this book to anyone looking at translational work with cell-based therapy. In a few succinct chapters the reader will understand who works in the field, what the issues with Read more...

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