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Programmed cells from basic neuroscience to therapy

Auteur: F Gage; Yves Christen
Uitgever: Berlin ; New York : Springer, ©2013.
Serie: Research and perspectives in neurosciences, v.20.
Editie/Formaat:   eBoek : Document : EngelsAlle edities en materiaalsoorten bekijken.
Database:WorldCat
Samenvatting:
The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For  Meer lezen...
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Genre/Vorm: Electronic books
Genre: Document, Internetbron
Soort document: Internetbron, Computerbestand
Alle auteurs / medewerkers: F Gage; Yves Christen
ISBN: 9783642366482 3642366481
OCLC-nummer: 844357575
Opmerkingen: Includes index.
Beschrijving: 1 online resource.
Inhoud: iPS Cell Technology and Disease Research: Issues To Be Resolved / Rudolf Jaenisch --
Therapeutic Somatic Cell Reprogramming by Nuclear Transfer / Stan Wang, John B. Gurdon --
Induction of Neural Lineages from Mesoderm and Endoderm by Defined Transcription Factors / Marius Wernig --
Proposing a Model for Studying Primate Development Using Induced Pluripotent Stem Cells / Maria C. N. Marchetto, Alysson R. Muotri --
HTT Evolution and Brain Development / Chiara Zuccato, Elena Cattaneo --
Human Pluripotent and Multipotent Stem Cells as Tools for Modeling Neurodegeneration / Jerome Mertens, Philipp Koch, Oliver Brüstle --
Human Stem Cell Approaches to Understanding and Treating Alzheimer's Disease / Lawrence S. B. Goldstein --
Potential of Stem Cell-Derived Motor Neurons for Modeling Amyotrophic Lateral Sclerosis (ALS) / Derek H. Oakley, Gist F. Croft --
Using Pluripotent Stem Cells to Decipher Mechanisms and Identify Treatments for Diseases That Affect the Brain / Marc Peschanski, Cécile Martinat --
Modeling Autism Spectrum Disorders Using Human Neurons / Alysson Renato Muotri --
On the Search for Reliable Human Aging Models: Understanding Aging by Nuclear Reprogramming / Ignacio Sancho-Martinez, Emmanuel Nivet.
Serietitel: Research and perspectives in neurosciences, v.20.
Verantwoordelijkheid: Fred H. Gage, Yves Christen, editors.
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Fragment:

Written by leading experts in the field, this book examines the latest research on neurodegenerative diseases and presents prospects for novel therapies.  Meer lezen...

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schema:description"The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson.s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called "disease-in-a-dish" approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases."
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