Find a copy online
Links to this item
Find a copy in the library
Finding libraries that hold this item...
|Additional Physical Format:||Print version:
Gage, Fred H.
Programmed Cells from Basic Neuroscience to Therapy.
Dordrecht : Springer, ©2013
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Fred H Gage; Yves Christen
|Notes:||Cell-Based Models for Identification and Testing Therapies.|
|Description:||1 online resource (137 pages).|
|Contents:||Programmed Cells from Basic Neuroscience to Therapy; Acknowledgments; Contents; Contributors; iPS Cell Technology and Disease Research: Issues To Be Resolved; Strategies for Deriving Reprogramming Factor-Free hiPS Cells; Genetic Modification of hES Cells and hiPS Cells; Markers for Differentiation; Generation of Isogenic Pairs of Disease-Specific and Control Cells; Outlook; References; Therapeutic Somatic Cell Reprogramming by Nuclear Transfer; Therapeutic Limitations of Reprogramming Techniques; NT to Enucleated Eggs; NT to Oocytes; Potential Therapeutic Benefits of NT Reprogramming. Phenotypical Assays for Comparative StudiesConclusion and Perspectives; References; HTT Evolution and Brain Development; The Evolutionary History of htt; Htt in Protostomes; Htt in Deuterostomes; Origin and Evolution of the htt polyQ in Deuterostomes; Htt Domains: A Focus on the NH2-Terminus; The Emerging Pro-neurulation Function of htt During Deuterostome Evolution; ADAM10, A New Target of htt in Neurulation; Conclusions; References; Human Pluripotent and Multipotent Stem Cells as Tools for Modeling Neurodegeneration; Introduction; lt-NES Cells as a Tool for hPSC-Based Disease Modeling. AD: Assessing and Modulating Endogenous Abeta Formation in Human NeuronsMachado-Joseph Disease: The Excitation-Aggregation Connection; Conclusion; References; Human Stem Cell Approaches to Understanding and Treating Alzheimer ́s Disease; Introduction; Human IPSC Models of FAD; The Problem of Genetic Background and Sporadic AD; Some Prospects for the Future; References; Potential of Stem Cell-Derived Motor Neurons for Modeling Amyotrophic Lateral Sclerosis (ALS); Motor Neuron Degeneration in ALS; Motor Neuron Subtype-Selective Disease Phenotypes; Need for a Humanized Model of ALS. Anatomy and Molecular Markers of Human Motor Neurons and Their SubtypesSpecification of Motor Neurons in Vitro from ES Cells; Yield and Purity of hES Cell-Derived Motor Neurons; Application of Stem Cell-Derived Motor Neurons to the Study of ALS; Concerns About Using iPS Cells as an Approach for Modeling ALS; Conclusion and Perspectives; References; Using Pluripotent Stem Cells to Decipher Mechanisms and Identify Treatments for Diseases That Affect the Brain; Modeling Monogenic Diseases with ES Cell Lines Derived from PGD Embryos; Monogenic Diseases Modeling Using Human iPS Cells.|
|Series Title:||Research and perspectives in neurosciences.|