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Programmed Cells from Basic Neuroscience to Therapy

Author: Fred H Gage; Yves Christen
Publisher: Dordrecht : Springer, 2013.
Series: Research and perspectives in neurosciences.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Gage, Fred H.
Programmed Cells from Basic Neuroscience to Therapy.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Fred H Gage; Yves Christen
ISBN: 9783642366482 3642366481
OCLC Number: 854975453
Notes: Cell-Based Models for Identification and Testing Therapies.
Description: 1 online resource (137 pages).
Contents: Programmed Cells from Basic Neuroscience to Therapy; Acknowledgments; Contents; Contributors; iPS Cell Technology and Disease Research: Issues To Be Resolved; Strategies for Deriving Reprogramming Factor-Free hiPS Cells; Genetic Modification of hES Cells and hiPS Cells; Markers for Differentiation; Generation of Isogenic Pairs of Disease-Specific and Control Cells; Outlook; References; Therapeutic Somatic Cell Reprogramming by Nuclear Transfer; Therapeutic Limitations of Reprogramming Techniques; NT to Enucleated Eggs; NT to Oocytes; Potential Therapeutic Benefits of NT Reprogramming. Phenotypical Assays for Comparative StudiesConclusion and Perspectives; References; HTT Evolution and Brain Development; The Evolutionary History of htt; Htt in Protostomes; Htt in Deuterostomes; Origin and Evolution of the htt polyQ in Deuterostomes; Htt Domains: A Focus on the NH2-Terminus; The Emerging Pro-neurulation Function of htt During Deuterostome Evolution; ADAM10, A New Target of htt in Neurulation; Conclusions; References; Human Pluripotent and Multipotent Stem Cells as Tools for Modeling Neurodegeneration; Introduction; lt-NES Cells as a Tool for hPSC-Based Disease Modeling. AD: Assessing and Modulating Endogenous Abeta Formation in Human NeuronsMachado-Joseph Disease: The Excitation-Aggregation Connection; Conclusion; References; Human Stem Cell Approaches to Understanding and Treating Alzheimer ́s Disease; Introduction; Human IPSC Models of FAD; The Problem of Genetic Background and Sporadic AD; Some Prospects for the Future; References; Potential of Stem Cell-Derived Motor Neurons for Modeling Amyotrophic Lateral Sclerosis (ALS); Motor Neuron Degeneration in ALS; Motor Neuron Subtype-Selective Disease Phenotypes; Need for a Humanized Model of ALS. Anatomy and Molecular Markers of Human Motor Neurons and Their SubtypesSpecification of Motor Neurons in Vitro from ES Cells; Yield and Purity of hES Cell-Derived Motor Neurons; Application of Stem Cell-Derived Motor Neurons to the Study of ALS; Concerns About Using iPS Cells as an Approach for Modeling ALS; Conclusion and Perspectives; References; Using Pluripotent Stem Cells to Decipher Mechanisms and Identify Treatments for Diseases That Affect the Brain; Modeling Monogenic Diseases with ES Cell Lines Derived from PGD Embryos; Monogenic Diseases Modeling Using Human iPS Cells.
Series Title: Research and perspectives in neurosciences.

Abstract:

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in.

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