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Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease

Author: James R Harris
Publisher: Dordrecht ; New York : Springer, ©2012.
Series: Sub-cellular biochemistry, 65.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: James R Harris
ISBN: 9789400754164 9400754167 9400754159 9789400754157 9781283936118 1283936119
OCLC Number: 822997147
Notes: Includes index.
Description: 1 online resource.
Contents: Introduction and technical survey: Protein aggregation and fibrillogenesis --
Fibril formation by short synthetic peptides --
In vitrooligomerization and fibrillogenesis of amyloid-beta peptides --
Tau fibrillogenesis --
Prion protein aggregation and fibrillogenesisin vitro --
Alpha-synuclein aggregation and modulating factors --
Pathological self-aggregation of [beta](2)-microglobulin: A challenge for protein biophysics --
Islet amyloid polypeptide: Aggregation and fibrillogenesisin vitroand its inhibition --
Mechanisms of transthyretin aggregation and toxicity --
Fibrillogenesis of huntingtin and other glutamine containing proteins --
Aggregation and fibrillogenesis of proteins not associated with disease: A few case studies --
Experimental inhibition of peptide fibrillogenesis by synthetic peptides, carbohydrates and drugs --
Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (abeta) and other disease-related peptides/proteins by plant extracts and herbal compounds --
Alzheimer's disease --
Modeling the polyglutamine aggregation pathway in huntington's disease: From basic studies to clinical applications --
Parkinson's disease --
Human prion diseases: From kuru to variant creutzfeldt-jakob disease --
Animal prion diseases --
[beta](2)-microglobulin amyloidosis --
Systemic AA amyloidosis --
Familial amyloidotic polyneuropathy and transthyretin --
The challenge of systemic immunoglobulin light-chain amyloidosis (AL)
Series Title: Sub-cellular biochemistry, 65.
Responsibility: J. Robin Harris, editor.
More information:

Abstract:

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, t

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