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Protein conformational dynamics

Author: Ke-Li Han; Xin Zhang; Ming-jun Yang
Publisher: Cham [Switzerland] : Springer, [2014] ©2014
Series: Advances in experimental medicine and biology, v. 805.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological  Read more...
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Additional Physical Format: Online version:
Protein conformational dynamics.
Cham ; New York : Springer, 2014
(OCoLC)873822128
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Ke-Li Han; Xin Zhang; Ming-jun Yang
ISBN: 9783319029696 331902969X
OCLC Number: 871193503
Description: xii, 488 pages : illustrations (some color) ; 24 cm.
Contents: Protein folding simulations by generalized-ensemble algorithms --
Application of Markov state models to simulate long timescale dynamics of biological macromolecules --
Understanding protein dynamics using conformational ensembles --
Generative models of conformational dynamics --
Generalized spring tensor models for protein fluctuation dynamics and conformational changes --
The joys and perils of flexible fitting --
Coarse-grained models of the proteins backbone conformational dynamics --
Simulating protein folding in different environmental conditions --
Simulating the peptide folding kinetic related spectra based on the Markov state model --
The dilemma of conformational dynamics in enzyme catalysis: perspectives from theory and experiment --
Exploiting intrinsic flexibility in drug design --
NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions --
Molecular dynamics simulation of membrane proteins --
Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics --
Coordination and control inside simple biomolecular machines --
Multi-state targeting machinery govern the fidelity and efficiency of protein localization --
Molecular dynamics simulations of F₁-ATPase --
Chemosensorial G-proteins-coupled receptors: a perspective from computational methods.
Series Title: Advances in experimental medicine and biology, v. 805.
Responsibility: Ke-li Han, Xin Zhang, Ming-jun Yang, editors.
More information:

Abstract:

"This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression"--Publisher's description.

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