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Protein degradation. Volume 1, Ubiquitin and the chemistry of life

Author: R J Mayer; Aaron J Ciechanover; Martin Rechsteiner
Publisher: Weinheim : Wiley-VCH, ©2005.
Series: Protein Degradation.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Protein degradation. Volume 1, Ubiquitin and the chemistry of life.
Weinheim : Wiley-VCH, ©2005
(OCoLC)56963518
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: R J Mayer; Aaron J Ciechanover; Martin Rechsteiner
ISBN: 3527605568 9783527605569 1280520620 9781280520624
OCLC Number: 68966600
Description: 1 online resource (1 volume) : illustrations.
Contents: Cover --
Contents --
Preface --
List of Contributors --
1 Brief History of Protein Degradation and the Ubiquitin System --
146;1 Introductory Remarks --
146;2 Protein Degradation 8211; Does It Exist63; --
146;3 Discovery of the Role of Ubiquitin in Protein Degradation --
146;4 Identification of Enzymes of the Ubiquitin45;mediated Proteolytic System --
146;5 Discovery of Some Basic Cellular Functions of the Ubiquitin System --
146;6 Concluding Remarks --
References --
2 N45;terminal Ubiquitination58; No Longer Such a Rare Modification --
Abstract --
246;1 Background --
246;2 Results --
246;3 Discussion --
Acknowledgments --
References --
3 Evolutionary Origin of the Activation Step During Ubiquitin45;dependent Protein Degradation --
Abbreviations --
Abstract --
346;1 Introduction --
346;146;1 Activation of Ubiquitin and Ubiquitin45;like Proteins --
346;146;2 Molybdenum Cofactor Biosynthesis --
346;2 The Crystal Structure of MoaD Reveals the Ubiquitin Fold --
346;3 Structural Studies of the MoeB8211;MoaD Complex --
346;346;1 Structure of MoeB --
346;346;2 The MoeB8211;MoaD Interface --
346;346;3 Structure of MoeB8211;MoaD with Bound ATP --
346;346;4 Structure of the MoaD Adenylate --
346;346;5 Fate of the Adenylate --
346;4 Structure of the NEDD8 Activator --
346;446;1 Overall Structure of the NEDD845;E1 --
346;446;2 Comparison with the MoaD8211;MoeB Complex --
346;446;3 Conformational Changes during the Formation of the Acyl Adenylate --
Summary --
Acknowledgments --
References --
4 RING Fingers and Relatives58; Determinators of Protein Fate --
446;1 Introduction and Overview --
446;146;1 Historical Perspective --
446;2 RING Fingers as E3s --
446;246;1 General Considerations --
446;246;2 Structural Analysis and Structure8211;Function Relationships --
446;246;3 Other Protein8211;Protein Interaction Motifs in RING finger Proteins --
446;246;4 Variations on the RING Finger --
446;246;5 High45;order Structure of RINGs 8211; TRIMs --
446;3 RING Fingers in Cell Signaling --
446;346;1 Siahs --
446;346;2 IAPs --
446;346;3 TRAFs --
446;346;4 Cbls --
446;4 Multi RING finger Proteins --
446;446;1 Mindbomb and TRIADs --
446;446;2 Parkin and Parkinson8217;s Disease --
446;5 Regulation of p53 by Mdm2 and other RING finger Proteins --
446;546;1 Mdm2 --
446;546;2 Pirh2 --
446;546;3 MdmX --
446;546;4 Arf and Other Modulators of Mdm2 Activity --
446;546;5 Other Potential Mdm2 Substrates --
446;546;6 Mdm2 and Therapeutic Intervention in Cancer --
446;6 Conclusion 8211; Perspective --
Acknowledgments --
References --
5 Ubiquitin45;conjugating Enzymes --
546;1 Introduction --
546;2 Historical Background --
546;3 What is an E263; --
546;4 Functional Diversity of Ubiquitin45;conjugating Enzymes --
546;446;1 Functions Related to Proteasome Proteolysis --
546;446;2 Endocytosis and Trafficking --
546;446;3 Non45;proteolytic Functions --
546;446;4 E2s of Uncertain Function --
546;446;5 E2 Enzymes and Disease.
Series Title: Protein Degradation.
Responsibility: John Mayer, Aaron Ciechanover, Martin Rechsteiner, eds.

Abstract:

A series of four topical volumes on the molecular biology and physiology of controlled protein breakdown in higher organisms via the ubiquitin-proteasome pathway. Edited by a trio of eminent  Read more...

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"This is a worthy reference book to have on your shelf." (The Biochemist, April 2008)

 
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