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Protein-ligand interactions : methods and applications

Author: G Ulrich Nienhaus
Publisher: Totowa, N.J. : Humana Press, ©2005.
Series: Methods in molecular biology (Clifton, N.J.), 305.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Molecular recognition and binding of ligands (atoms, ions, and molecules) by proteins with high sensitivity and selectivity is of central importance to essentially all biomolecular processes and of key importance for the basic and applied sciences. In Protein-Ligand Interactions: Methods and Applications, leading experts with hands-on experience describe in detail a broad selection of established and emerging  Read more...
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Genre/Form: Fulltext
Internet Resource
Laboratory Manual
Electronic books
Laboratory manuals
Laboratory Manuals
Additional Physical Format: Print version:
Protein-ligand interactions.
Totowa, N.J. : Humana Press, ©2005
(DLC) 2004042387
(OCoLC)56414984
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: G Ulrich Nienhaus
ISBN: 1588293726 9781588293725 1592599125 9781592599127
OCLC Number: 61264170
Description: 1 online resource (xi, 568 pages) : illustrations.
Contents: Isothermal titration calorimetry --
Direct optical detection of protein-ligand interactions --
Label-free detection of protein-ligand interactions by the quartz crystal microbalance --
Measurement of solvent accessibility at protein-protein interfaces --
Hydrophobic interaction chromatography: harnessing multivalent protein-surface interactions for purification procedures --
Sedimentation velocity method in the analytical ultracentrifuge for the study of protein-protein interactions --
Protein-ligand interaction probed by time-resolved crystallography --
X-ray crystallography of protein-ligand interactions --
Combined use of XAFS and crystallography for studying protein-ligand interactions --
Probing heme protein-ligand interactions by UV/visible absorption spectroscopy --
Ultrafast time-resolved IR studies of protein-ligand interactions --
Monitoring protein-ligand interactions by time-resolved FTIR difference spectroscopy --
Proteins in motion: resonance raman spectroscopy as a probe of functional intermediates --
Fluorescence polarization/anisotropy approaches to study protein-ligand interactions: effects of errors and uncertainties --
Ligand binding with stopped-flow rapid mixing --
Circular dichroism spectroscopy for the study of protein-ligand interactions --
High throughput screening of interactions between G protein-coupled receptors and ligands using confocal optics microscopy --
Single-molecule study of protein-protein and protein-DNA interaction dynamics --
Application of fluorescence correlation spectroscopy to hapten-antibody binding --
Atomic force microscopy measurements of protein-ligand interactions on living cells --
Computer simulation of protein-ligand interactions: challenges and applications --
Force probe molecular dynamics simulations --
Study of ligand-protein interactions by means of density functional theory and first-principles molecular dynamics.
Series Title: Methods in molecular biology (Clifton, N.J.), 305.
Responsibility: edited by G. Ulrich Nienhaus.
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Abstract:

A readily reproducible collection of established and emerging techniques for studying the interaction between proteins and ligands, including biochemical/bulk techniques, structure analysis,  Read more...

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