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Protein-metal interactions; [proceedings]

Author: Mendel Friedman; American Chemical Society.
Publisher: New York, Plenum Press [1974]
Series: Advances in experimental medicine and biology, v. 48.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
Metal ions and proteins are ubiquitous. Therefore, not surprisingly, new protein-metal interactions continue to be discovered, and their importance is increasingly recognized in both physical and life sciences. Because the subject matter is so broad and affects so many disciplines, in organizing this Symposium, I sought participation of speakers with the broadest possible range of interests. Twenty-two accepted my  Read more...
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Genre/Form: Congresses
Conference papers and proceedings
Congrès
Additional Physical Format: Online version:
American Chemical Society Symposium on Protein-Metal Interactions (1973 : Chicago, Ill.).
Protein-metal interactions.
New York, Plenum Press [1974]
(OCoLC)644112158
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Mendel Friedman; American Chemical Society.
ISBN: 0306390485 9780306390487
OCLC Number: 984029
Description: x, 692 pages illustrations 26 cm.
Contents: 1. The Evolution of Metals as Essential Elements with special reference to iron and copper.- 2. The Functional Roles of Metals in Metallo Enzymes.- 3. Studies on Carboxypeptidase A.- 4. Zinc-Wool Keratin Reactions in Nonaqueous Solvents.- 5. Heme-Protein-Ligand Interactions.- 6. 13C NMR Studies of the Interaction of Hb and Carbonic Anhydrase with 13CO2.- 7. The Anion-Binding Functions of Transferrin.- 8. Lactoferrin Conformation and Metal Binding Properties.- 9. Physicochemical Studies of Ca++ Controlled Antigen Antibody Systems.- 10. Calcium Binding to Elastin.- 11. The Coordination of Calcium Ions by Carp Muscle Calcium-Binding Proteins A, B, and C.- 12. Ferroxidases and Ferrireductases: Their Role in Iron Metabolism.- 13. Copper and Amine Oxidases in Connective Tissue Metabolism.- 14. Copper- and Zinc-Binding Components in Rat Intestine.- 15. Metal-Albumin-Amino Acid Interactions: Chemical and Physiological Interrelationships.- 16. The Effect of Zinc Deprivation on the Brain.- 17. Biochemical and Electron Microscopic Studies of Rat Skin During Zinc Deficiency.- 18. Nickel Deficiency in Chicks and Rats: Effects on Liver Morphology, Functional and Polysomal Integrity.- 19. Selenium Catalysis of Swelling of Rat Liver Mitochondria and Reduction of Cytochrome c by Sulfur Compounds.- 20. Childhood Exposure to Environmental Lead.- 21. Cellular Effects of Lead.- 22. Distribution, Tissue Binding and Toxicity of Mercurials.- 23. Interactions of Mercury Compounds with Wool and Related Biopolymers.- 24. Interactions of Keratins With Metal Ions: Uptake Profiles, Mode of Binding, and Effects on Properties of Wool.- 25. X-Ray Photoelectron Spectroscopic Studies of Biological Materials. Metal Ion Protein Binding and Other Analytical Applications.- 26. Metal Analysis in Biological Material by Energy Dispersive X-Ray Fluorescence Spectroscopy.- 27. The Application of Perturbed Directional Correlation of Gamma Rays to the Study of Protein-Metal Interactions.
Series Title: Advances in experimental medicine and biology, v. 48.
Responsibility: Edited by Mendel Friedman.

Abstract:

Metal ions and proteins are ubiquitous. Therefore, not surprisingly, new protein-metal interactions continue to be discovered, and their importance is increasingly recognized in both physical and life sciences. Because the subject matter is so broad and affects so many disciplines, in organizing this Symposium, I sought participation of speakers with the broadest possible range of interests. Twenty-two accepted my invitation. To supplement the verbal presentations, the Proceedings include five closely related invited contributions. The ideas expressed are those of the various authors and are not necessarily approved or rejected by any agency of the United States Government. No official recommendation concerning the subject matter or products discussed is implied in this book. This book encompasses many aspects of this multifaceted field. Topics covered represent biochemical, immunochemical, bioorganic, biophysical, metabolic, nutritional, medical, physiological, toxicological, environmental, textile, and analytical interests. The discoveries and developments in any of these areas inevitably illumine others. I feel that a main objective of this Symposium, bringing together scientists with widely varied experiences yet with common interests in protein-metal interactions, so that new understanding and new ideas would result has been realized. I hope that the reader enjoys and benefits from reading about the fascinating interactions of metal ions and proteins as much as I did. Although an adequate summary of the Symposium is not possible in a brief preface, I wish to express particular interest in the ideas reported by Professor Frieden: that the relative occurrence and participation of the various metals as essential elements in enzyme action and other life processes is an adaptive relationship to their relative abundance in the ocean. Undoubtedly, this adaptation is a continuing process. A more immediate practical concern voiced by D.K. Darrow and H.A. Schroeder that has received widespread publicity and debate is that children are highly susceptible to lead poisoning and that their exposure to lead nowadays comes mainly from automobile exhaust. Of the invited contributions supplementing the Symposium, the paper by J.T. MacGregor and T.W. Clarkson deserves special mention. Dr. MacGregor collaborated with Dr. Clarkson, his former major professor, in this thorough review while the latter was out of the country dealing directly with an episode of mercury poisoning described in their paper. I believe their critical compilation of tissue distribution and toxicity of mercury compounds will greatly benefit the medical and other scientific communities in dealing with this useful but dangerous element. to lead poisoning and that their exposure to lead nowadays comes mainly from automobile exhaust. Of the invited contributions supplementing the Symposium, the paper by J.T. MacGregor and T.W. Clarkson deserves special mention. Dr. MacGregor collaborated with Dr. Clarkson, his former major professor, in this thorough review while the latter was out of the country dealing directly with an episode of mercury poisoning described in their paper. I believe their critical compilation of tissue distribution and toxicity of mercury compounds will greatly benefit the medical and other scientific communities in dealing with this useful but dangerous element.

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