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Protein misfolding and disease : principles and protocols

Author: Peter Bross; Niels Gregersen
Publisher: Totowa, N.J. : Humana Press, ©2003.
Series: Methods in molecular biology (Clifton, N.J.), v. 232.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
It has now become clear that a large number of diseases with very different pathologies share a common framework of protein misfolding, accompanied by degradation and/or aggregation of the misfolded proteins. In Protein Misfolding and Disease: Principles and Protocols, notable experts in conformational disease review the latest thinking about the molecular processes underlying these diseases and describe  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Laboratory Manuals
Additional Physical Format: Print version:
Protein misfolding and disease.
Totowa, N.J. : Humana Press, ©2003
(DLC) 2002192191
(OCoLC)51222232
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Peter Bross; Niels Gregersen
ISBN: 1588290654 9781588290656 9781592593941 1592593941
OCLC Number: 171234518
Description: 1 online resource (xv, 318 pages) : illustrations.
Contents: Protein misfolding, aggregation, and degradation in disease / N. Gregersen, L. Bolund and P. Bross --
Basic introduction to in vivo protein folding and its defects / P. Bross and N. Gregersen --
Cystic fibrosis: Premature degradation of mutant proteins as a molecular disease mechanism / M.S. Gelman and R.R. Kopito --
Alpha1-antitrypsin deficiency: Liver disease associated with retention of a mutant secretory glycoprotein in the endoplasmic reticulum / D.H. Perlmutter --
Parkinson's disease: Alpha-synuclein and parkin in protein aggregation and the reversal of unfolded protein stress / L.D. Jakobsen and P.H. Jensen --
Aberrant protein folding as the molecular basis of cancer / M.D. Scott and J. Frydman --
Yeast as a model system to investigate protein conformational diseases / C.M. Coughlan and J.L. Brodsky --
Expression of recombinant proteins: An introduction / J. Nohr, K. Kristiansen and A.M. Krogsdam --
Expression in e. Coli systems / A.M. Krogsdam, K. Kristiansen and J. Nohr --
Protein expression in yeasts / J. Nohr, K. Kristiansen and A.M. Krogsdam --
Site-directed mutagenesis / J. Nohr and K. Kristiansen --
Pulse-chase labeling techniques for the analysis of protein maturation and degradation / A. Jansens and I. Braakman --
Detection of aggregates and protein inclusions by staining of tissues / J.E. Galvin --
Study of mutant proteins with folding defects in cultured patient cells / G. Dodt and C. Walter --
E. Coli expression system for identifying folding mutations of human adenosine deaminase / I. Santisteban [and others] --
Characterization of overexpressed mutant proteins in mammalian cells / T.J. Corydon --
Investigation of unfolded-protein response in cells expressing familial alzheimer's disease-linked presenilin variants / G. Thinakaran [and others] --
Huntingtin fragments form aggresome-like inclusion bodies in mammalian cells / A. Boeddrich, R. Lurz and E.E. Wanker --
Application of chemical chaperones to the rescue of folding defects / T.W. Loo and D.M. Clarke --
Analysis of defective subunit interactions using the two-hybrid system / B. Perez, L.R. Desviat and M. Ugarte --
Investigation of folding and degradation of in vitro synthesized mutant proteins in the cytosol / L.R. Desviat, B. Perez and M. Ugarte --
Investigation of folding and degradation of in vitro synthesized mutant proteins in microsomes / A.W. Cuthbert and W. Fuller --
Investigation of folding and degradation of in vitro synthesized mutant proteins in mitochondria / P. Bross [and others] --
Investigation of folding and degradation of mutant proteins synthesized in semipermeabilized cells / C.M. Wilson and N.J. Bulleid.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 232.
Responsibility: edited by Peter Bross, Niels Gregersen.

Abstract:

In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological  Read more...

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"...a very sound book that provides a solid background in conformational disease and presents the reader with helpful experimental protocols for studying protein folding folding and misfolding." - Read more...

 
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