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Protein misfolding in neurodegenerative diseases : mechanisms and therapeutic strategies

Author: H J Smith; Claire Simons; Robert D E Sewell
Publisher: Boca Raton, FL : CRC Press, ©2008.
Series: CRC enzyme inhibitors series.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Describes the findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. This book covers the diverse biochemical targets/markers  Read more...

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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: H J Smith; Claire Simons; Robert D E Sewell
ISBN: 9780849373107 0849373107
OCLC Number: 130566692
Description: xxiv, 565 pages, [4] pages of plates : illustrations (some color) ; 25 cm.
Contents: Protein folding and misfolding, relevance to disease, and biological function / Massimo Stefani --
Alzheimer's disease / Charlotte E. Teunissen and Tischa J.M. van der Cammen --
Improving cholinergic transmission --
Cholinergic transmission and acetylcholine release enhancers / Pierre Francotte, Pascal de Tullio, and Bernard Pirotte --
AChE and its inhibition / Jure Stojan --
AChE inhibitors and their clinical assessment / Pierre Francotte, Pascal de Tullio, and Bernard Pirotte --
Reduction in plaque formation --
Secretase and APP processing / Christian Czech, Helmut Jacobsen, and Celine Adessi --
Mechanism of plaque formation and Aß aggregation inhibitors / Christian Czech, Helmut Jacobsen, and Celine Adessi --
Nonsteroidal anti-inflammatory drugs / Bruno P. Imbimbo and Francesca Speroni --
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors / Dario Cattaneo --
Aß polymerization reduction / Harry LeVine III and Corrine E. Augelli-Szafran --
Carbonic anhydrase activators as potential anti-Alzheimer's disease agents / Claudiu T. Supuran and Andrea Scozzafava --
Detection and reduction of neurofibrillary lesions / Jeff Kuret --
Protein misfolding in Alzheimer disease : pathogenic or protective? / Rudy J. Castellani [and others] --
Enhancement of brain retinoic acid levels / Ann B. Goodman [and others] --
Parkinson's disease : what is it? what causes it? and how can it be cured? / Tom Foltynie, Andrew W. Michell, and Roger A. Barker --
Restoring dopamine levels / P. Nuno Palma . [and others] --
Huntington's disease / Claire-Anne Gutekunst and Fran Norflus --
Amyotrophic lateral sclerosis (motor neuron disease) / Teresa Sanelli [and others] --
Transmissible spongiform encephalopathies / Michael D. Geschwind and Giuseppe Legname --
Overview / H. John Smith, Robert D.E. Sewell, and Claire Simons.
Series Title: CRC enzyme inhibitors series.
Responsibility: edited by H. John Smith, Claire Simons, Robert D.E. Sewell.
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