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Protein-nanoparticle interactions : the bio-nano interface

Author: Masoud Rahman
Publisher: Berlin ; New York : Springer, ©2013.
Series: Springer series in biophysics, 15.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Rahman, Masoud.
Protein-nanoparticle interactions.
Heidelberg : Springer, [2013]
(DLC) 2013941547
(OCoLC)857523741
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Masoud Rahman
ISBN: 9783642375552 3642375553 1299860109 9781299860100
OCLC Number: 852253700
Description: 1 online resource.
Contents: The Biological Significance of "Nano"-interactions --
Nanoparticle and Protein Corona --
Protein Corona: Applications and Challenges --
Analytical Methods for Corona Evaluations.
Series Title: Springer series in biophysics, 15.
Responsibility: Masoud Rahman [and others].

Abstract:

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a "biological identity" to their surfaces (referred to as a "corona"), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called "bio-nano interface," has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.

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